{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:56:07Z","timestamp":1793508967418,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of Cushing\u2019s disease (CD) and adrenal-dependent Cushing\u2019s syndrome (ACS) on bone mineral density (BMD) and bone metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were retrospectively collected for 55 patients with hypercortisolism (CD, n\u2009=\u200934; ACS n\u2009=\u200921) from January 1997 to June 2014. BMD was examined in all patients, and bone turnover markers were tested in some patients. Healthy controls (n\u2009=\u200918) were also recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The lumbar spine and femoral neck BMD were significantly lower in the ACS and CD groups than in the control group. Lumbar BMD was significantly lower in the ACS than CD group. The collagen breakdown product (CTX) concentrations were significantly higher while the osteocalcin and procollagen type I N-terminal propeptide (PINP) concentrations were significantly lower in the ACS and CD groups than in the control group. The PINP concentration was significantly lower while the CTX concentration was significantly higher in the ACS than CD group. In the CD group only, lumbar BMD and serum adrenocorticotropic hormone had a significant positive correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bone turnover markers indicated suppressed osteoblast and enhanced osteoclast activities. PINP and CTX changes might indicate bone mass deterioration. Adrenocorticotropic hormone might be protective for lumbar BMD in patients with CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517725660","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T01:54:55Z","timestamp":1504058095000},"page":"492-503","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Effect of hypercortisolism on bone mineral density and bone metabolism: A potential protective effect of adrenocorticotropic hormone in patients with Cushing\u2019s disease"],"prefix":"10.1177","volume":"46","author":[{"given":"Weihong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonggui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghua","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiehong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqiu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongshu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Endocrinology, McGill University Health Centre Research Institute, Decarie Boulevard, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, <!---->Tianjin Medical University General Hospital<!---->, No. 154 Anshan Road, Heping District, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"137","article-title":"The basophil adenomas of the pituitary body and their clinical manifestation (pituitary basophilism)","volume":"50","author":"Cushing H.","year":"1932","unstructured":"Cushing H. The basophil adenomas of the pituitary body and their clinical manifestation (pituitary basophilism). Bull Johns Hopkins Hosp 1932; 50: 137\u2013195","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000061073"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460051"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-005-1051-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12812"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1616-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302006000400013"},{"key":"e_1_3_3_10_2","first-page":"1863","article-title":"Alterations of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: study in eumenorrheic patients with Cushing\u2019s syndrome","volume":"83","author":"Chiodini I","year":"1998","unstructured":"Chiodini I, Carnevale V, Torlontano M, et al. 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