{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:51:03Z","timestamp":1793652663327,"version":"4.5.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elucidate the clinical significance of macrophage migration inhibitory factor (MIF) serum concentration in patients with polymyositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-six patients with polymyositis were enrolled. Serum samples were obtained and stored to detect MIF and interleukin (IL)-6 using commercially available enzyme-linked immunosorbent assay kits. The relationships between these cytokines and clinical data were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum MIF concentration was significantly lower in patients in remission (34.74\u2009\u00b1\u200917.75) and in healthy controls (38.87\u2009\u00b1\u20099.30\u2009ng\/ml) than that in patients with active polymyositis (50.04\u2009\u00b1\u200923.84\u2009ng\/ml). There were no significant differences between healthy controls and patients in remission. The serum IL-6 concentration in patients with active polymyositis (19.67\u2009\u00b1\u20097.16\u2009pg\/ml) was significantly higher than that in patients in remission (15.81\u2009\u00b1\u20094.00\u2009pg\/ml) and controls (8.14\u2009\u00b1\u20093.71\u2009pg\/ml). The serum IL-6 concentration was negatively correlated with the serum MIF concentration (r\u2009=\u2009\u22120.283). No relationship was found between the serum MIF concentration and glucocorticoid dose. The MIF concentration peaked twice during treatment when the creatine kinase concentration was decreasing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MIF and IL-6 play important roles in the inflammation associated with polymyositis. MIF might also be involved in the early stage of regeneration in polymyositis. MIF may thus serve as a biomarker of disease activity and outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517726194","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T05:20:02Z","timestamp":1505366402000},"page":"732-738","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Roles of macrophage migration inhibitory factor in polymyositis: Inflammation and regeneration"],"prefix":"10.1177","volume":"46","author":[{"given":"Yu-Qiong","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Zhejiang Provincial People\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zhejiang Provincial People\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Song","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Zhejiang Provincial People\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"bibr1-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"bibr2-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/art.34659"},{"key":"bibr3-0300060517726194","first-page":"101","volume":"53","author":"Shinjo SK","year":"2013","journal-title":"Rev Bras Reumatol"},{"key":"bibr4-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100133"},{"key":"bibr5-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-50"},{"key":"bibr6-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181e10925"},{"key":"bibr7-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"bibr8-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"bibr9-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1038\/377068a0"},{"key":"bibr10-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1038\/ni720"},{"key":"bibr11-0300060517726194","first-page":"1038","volume":"31","author":"Santos LL","year":"2004","journal-title":"J Rheumatol"},{"key":"bibr12-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/art.20190"},{"key":"bibr13-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601103200"},{"key":"bibr14-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1895"},{"key":"bibr15-0300060517726194","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00577"},{"key":"bibr16-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/art.24936"},{"key":"bibr17-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/art.34659"},{"key":"bibr18-0300060517726194","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535413"},{"key":"bibr19-0300060517726194","first-page":"268","volume":"31","author":"Foote A","year":"2004","journal-title":"J Rheumatol"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060517726194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060517726194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060517726194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:16Z","timestamp":1777459696000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060517726194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1177\/0300060517726194"],"URL":"https:\/\/doi.org\/10.1177\/0300060517726194","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}