{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:21:01Z","timestamp":1790799661038,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nocturnal hypoventilation (NH) is a complication of respiratory involvement in neuromuscular disorders (NMD) that can evolve into symptomatic daytime hypercapnia if not treated proactively with non-invasive ventilation. This study aimed to assess whether NH can be detected in the absence of other signs of nocturnal altered gas exchange.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed nocturnal transcutaneous coupled (tc) pCO\n                      <jats:sub>2<\/jats:sub>\n                      \/SpO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring in 46 consecutive cases of paediatric-onset NMD with a restrictive respiratory defect (forced vital capacity\u2009&lt;\u200960%). Nocturnal hypoventilation was defined as tcPCO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009&gt;\u200950 mmHg for\u2009&gt;\u200925% of recorded time, and hypoxemia as tcSpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009&lt;\u200988% for\u2009&gt;\u20095 minutes. Daytime symptoms and bicarbonate were recorded after overnight monitoring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-nine of 46 consecutive patients showed NH. Twenty-three patients did not have nocturnal hypoxemia and 18 were clinically asymptomatic. In 20 patients, PaCO\n                      <jats:sub>2<\/jats:sub>\n                      in daytime blood samples was normal. Finally, 13\/29 patients with NH had isolated nocturnal hypercapnia without nocturnal hypoxia, clinical NH symptoms, or daytime hypercapnia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Paediatric patients with NMD can develop NH in the absence of clinical symptoms or significant nocturnal desaturation. Therefore, monitoring of NH should be included among nocturnal respiratory assessments of these patients as an additional tool to determine when to commence non-invasive ventilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517728857","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T05:35:48Z","timestamp":1512538548000},"page":"1153-1161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Detection of early nocturnal hypoventilation in neuromuscular disorders"],"prefix":"10.1177","volume":"46","author":[{"given":"Federica","family":"Trucco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pedemonte","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Neurology and Muscle Disease, Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Neurology and Muscle Disease, Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-leng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Carlucci","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation, Fondazione S Maugeri, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Brisca","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Neurology and Muscle Disease, Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tacchetti","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Neurology and Muscle Disease, Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bruno","sequence":"additional","affiliation":[{"name":"Center of Myology and Neurodegenerative Disorders, Istituto Giannina Gaslini, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Minetti","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Neurology and Muscle Disease, Istituto Giannina Gaslini, Genova, 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