{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:03:26Z","timestamp":1777727006914,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the impact of goal-oriented hemoperfusion (HP) with monitoring of the paraquat concentration on the prognosis of patients with acute paraquat poisoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study involved patients with acute paraquat poisoning admitted from March 2012 to September 2015. The patients received either goal-oriented or routine HP. All other treatments were the same between the two groups. The primary endpoint was 28-day mortality after poisoning. The secondary endpoints were the incidence of organ dysfunction within 7 days and 7-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-four patients were enrolled (49 in the control group and 35 in the goal-oriented group). The two groups were similar in terms of clinical characteristics. There was no significant difference in the incidence of organ dysfunction between the two groups within 1 week of admission. Mortality on day 7 was significantly lower in the goal-oriented than control group, but there was no difference on day 28. However, 28-day mortality was significantly lower in the goal-oriented group among patients with an oral dose of \u226450 ml.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HP with monitoring of the urine paraquat concentration as goal-oriented therapy can reduce the early mortality of paraquat poisoning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517734917","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T06:49:02Z","timestamp":1509346142000},"page":"1091-1102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic comparison of goal-oriented hemoperfusion and routine hemoperfusion combined with continuous venovenous hemofiltration for paraquat poisoning"],"prefix":"10.1177","volume":"46","author":[{"given":"Xuming","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"bibr1-0300060517734917","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050049"},{"key":"bibr2-0300060517734917","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048397"},{"key":"bibr3-0300060517734917","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04026.x"},{"key":"bibr4-0300060517734917","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2013.834361"},{"key":"bibr5-0300060517734917","first-page":"263","volume":"27","author":"Jin K","year":"2015","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"bibr6-0300060517734917","volume-title":"Paraquat poisoning: Mechanisms, prevention, treatment","author":"Bismuth C","year":"1995"},{"key":"bibr7-0300060517734917","volume-title":"Textbook of medicine","author":"Proudfoot 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