{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:04:06Z","timestamp":1777727046557,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,1,14]],"date-time":"2018-01-14T00:00:00Z","timestamp":1515888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g\/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T\n                      <jats:sub>0<\/jats:sub>\n                      ), skin incision (T\n                      <jats:sub>1<\/jats:sub>\n                      ), cutting the gallbladder (T\n                      <jats:sub>2<\/jats:sub>\n                      ), suturing the peritoneum (T\n                      <jats:sub>3<\/jats:sub>\n                      ), skin closure (T\n                      <jats:sub>4<\/jats:sub>\n                      ), sputum suction (T\n                      <jats:sub>5<\/jats:sub>\n                      ), extubation (T\n                      <jats:sub>6<\/jats:sub>\n                      ) and 1 min (T\n                      <jats:sub>7<\/jats:sub>\n                      ), 5 min (T\n                      <jats:sub>8<\/jats:sub>\n                      ), 10 min (T\n                      <jats:sub>9<\/jats:sub>\n                      ), and 15 min (T\n                      <jats:sub>10<\/jats:sub>\n                      ) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T\n                      <jats:sub>7<\/jats:sub>\n                      , T\n                      <jats:sub>8<\/jats:sub>\n                      , T\n                      <jats:sub>9<\/jats:sub>\n                      and T\n                      <jats:sub>10<\/jats:sub>\n                      were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T\n                      <jats:sub>5<\/jats:sub>\n                      , T\n                      <jats:sub>6<\/jats:sub>\n                      , T\n                      <jats:sub>7<\/jats:sub>\n                      and T\n                      <jats:sub>8<\/jats:sub>\n                      ; and the Steward recovery scores at T\n                      <jats:sub>7<\/jats:sub>\n                      and T\n                      <jats:sub>8<\/jats:sub>\n                      were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517744957","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T08:14:25Z","timestamp":1516004065000},"page":"1063-1072","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial"],"prefix":"10.1177","volume":"46","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Jiangning Hospital Af\ufb01liated to Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-You","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jiangning Hospital Af\ufb01liated to Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jiangning Hospital Af\ufb01liated to Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, First People's Hospital of Shanghai Affiliated to Nanjing Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Toxicology (Ministry of Education), School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, 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