{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:11:31Z","timestamp":1780351891765,"version":"3.54.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,1,14]],"date-time":"2018-01-14T00:00:00Z","timestamp":1515888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether pre-treatment with high-dose ulinastatin provides enhanced postoperative oxygenation in patients who have undergone aortic valve surgery with moderate hypothermic cardiopulmonary bypass (CPB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients who underwent aortic valve surgery with moderate hypothermic CPB were retrospectively evaluated. In total, 94 of 146 patients were included. The patients were classified into one of two groups: patients in whom ulinastatin (10,000 U\/kg followed by 5,000 U\/kg\/h) was administered during CPB (Group U, n\u2009=\u200938) and patients in whom ulinastatin was not administered (Group C, n\u2009=\u200956). The PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio was calculated at the following time points: before CPB (pre-CPB), 2 h after weaning from CPB (post-CPB), and 6 h after arrival to the intensive care unit (ICU-6). The incidence of a low PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio was also compared among the time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Group U showed a significantly higher PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio (F(4, 89.0)\u2009=\u2009657.339) and a lower incidence of lung injury (PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio\u2009&lt;\u2009300) than Group C at the post-CPB and ICU-6 time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High-dose ulinastatin improved pulmonary oxygenation after CPB and in the early stages of the ICU stay in patients undergoing aortic valve surgery with CPB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517746841","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T08:14:31Z","timestamp":1516004071000},"page":"1238-1248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["High-dose ulinastatin improves postoperative oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass: A retrospective study"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-5521","authenticated-orcid":false,"given":"Ka-Young","family":"Rhee","sequence":"first","affiliation":[{"name":"Department Anaesthesiology, Konkuk University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-1477","authenticated-orcid":false,"given":"Tae-Yun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Konyang University College of Medicine, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Deok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Kosin University School of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Chung-Ang University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazri","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Perfusion, Hospital Tengku Ampuan Afzan, Kuantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yop","family":"Kim","sequence":"additional","affiliation":[{"name":"Department Anaesthesiology, Konkuk University School of Medicine, Seoul, Korea"},{"name":"Department of Anaesthesiology, Konkuk University Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,14]]},"reference":[{"key":"bibr1-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200207000-00030"},{"key":"bibr2-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00093-4"},{"key":"bibr3-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1007\/BF00941649"},{"key":"bibr4-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009470"},{"key":"bibr5-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01433-2"},{"key":"bibr6-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.08.166"},{"key":"bibr7-0300060517746841","doi-asserted-by":"publisher","DOI":"10.3109\/08860229609047715"},{"key":"bibr8-0300060517746841","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.150736"},{"key":"bibr9-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000215110.55899.AE"},{"key":"bibr10-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.11.001"},{"key":"bibr11-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113973"},{"key":"bibr12-0300060517746841","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.12.015"},{"key":"bibr13-0300060517746841","doi-asserted-by":"publisher","DOI":"10.3109\/00365519109104564"},{"key":"bibr14-0300060517746841","first-page":"497","volume":"48","author":"Bingyang 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