{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:04:25Z","timestamp":1777727065277,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis is a complex clinical condition caused by a dysregulated immune response to an infection resulting in a fatal outcome. This study aimed to investigate the value of urine soluble triggering receptor expressed on myeloid cells (sTREM-1) for diagnosing culture-proven sepsis in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Preterm neonates were evaluated for late-onset sepsis (LOS). Laboratory investigations were performed. Urine sTREM-1 samples and blood cultures were synchronously collected. Using blood culture results, preterm neonates were divided into the culture-proven group and suspected sepsis group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of preterm 62 infants were included in the study; 31 had culture-proven sepsis and 31 were suspected as having sepsis. There were no significant differences in gestational age, sex, birth weight, and delivery mode between the groups. Neonates in the culture-proven group had significantly higher urine sTREM-1 levels than did those in the suspected sepsis group. Using a cut-off point for a urine sTREM-1 level of 78.5 pg\/mL, the sensitivity was 0.90, specificity was 0.78, positive predictive value was 0.68, and negative predictive value was 0.94.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study highlights the role of urine sTREM-1 levels in LOS. Urine sTREM-1 may be a reliable and sensitive marker in detecting sepsis in preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517749131","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T07:51:37Z","timestamp":1519631497000},"page":"1606-1616","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic value of urine soluble triggering receptor expressed on myeloid cells (sTREM-1) for late-onset neonatal sepsis in infected preterm neonates"],"prefix":"10.1177","volume":"46","author":[{"given":"Senem","family":"Alkan Ozdemir","sequence":"first","affiliation":[{"name":"Department of Neonatology, Behcet Uz Children\u2019s Hospital, Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra Arun","family":"Ozer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Mugla Sitki Ko\u00e7man University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozkan","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Tepecik Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumer","family":"Sutcuoglu","sequence":"additional","affiliation":[{"name":"Tepecik Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansur","family":"Tatl\u0131","sequence":"additional","affiliation":[{"name":"Izmir Katip \u00c7elebi University School of Medicine, Department of Neonatology, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"bibr1-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.025171"},{"key":"bibr2-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"bibr3-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fe3d28"},{"key":"bibr4-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1689"},{"key":"bibr5-0300060517749131","first-page":"201","volume":"1","author":"Meem M","year":"2011","journal-title":"J Glob Health"},{"key":"bibr6-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.05.005"},{"key":"bibr7-0300060517749131","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-1-200407060-00009"},{"key":"bibr8-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.09.021"},{"key":"bibr9-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701199832"},{"key":"bibr10-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031544"},{"key":"bibr11-0300060517749131","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903009248"},{"key":"bibr12-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.10.013"},{"key":"bibr13-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.12.003"},{"key":"bibr14-0300060517749131","first-page":"19","volume":"8","author":"El-Mazary A","year":"2010","journal-title":"Egypt J Pediatr Allergy Immunol"},{"key":"bibr15-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31825691e4"},{"key":"bibr16-0300060517749131","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu079"},{"key":"bibr17-0300060517749131","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.607663"},{"key":"bibr18-0300060517749131","first-page":"50","volume":"52","author":"Turkish Neonatal Society; 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