{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:54:08Z","timestamp":1782824048102,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was performed to analyze the risk factors for early mortality (EM) in elderly patients undergoing treatment for multiple myeloma (MM) in real-world clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data from 108 elderly patients who were newly diagnosed with MM from January 2007 to July 2015 were analyzed in a single hematology center. EM was defined as death of any cause within 12 months after diagnosis. A multivariate regression model was used to evaluate EM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EM occurred in 16 (14.8%) elderly patients with newly diagnosed MM. The most common cause of death was infection (10\/16, 62.5%). In the multivariate analysis, only an age of \u226575 years, International Staging System (ISS) stage III disease, and high lactate dehydrogenase concentration were significantly and independently associated with EM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that infection is the leading cause of EM in elderly patients with MM. An age of \u226575 years, ISS stage III disease, and a high lactate dehydrogenase concentration are significant predictors of EM. We should further target this higher-risk patient population to define personalized therapy with which to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518757640","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T15:14:18Z","timestamp":1522163658000},"page":"2230-2237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Early mortality in elderly patients undergoing treatment for multiple myeloma in real-world practice"],"prefix":"10.1177","volume":"46","author":[{"given":"Jun","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6272-2955","authenticated-orcid":false,"given":"Hongfeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wuxi People\u2019s Hospital, Nanjing Medical 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