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Neurohormonal systems play a critical role in cardiovascular homeostasis, pathophysiology, and cardiovascular diseases. Hormone treatments such as the newly invented dual-acting drug valsartan\/sacubitril are promising candidates for CHF, in addition to the conventional medications encompassing beta receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists. Clinical trials also indicate that in CHF patients with low insulin-like growth factor-1 or low thyroid hormone levels, supplemental treatment with growth hormone or thyroid hormone seems to be cardioprotective; and in CHF patients with volume overload the vasopressin antagonists can relieve the symptoms superior to loop diuretics. Furthermore, a combination of selective glucocorticoid receptor agonist and mineralocorticoid receptor antagonist may be used in patients with diuretic resistance. Finally, the potential cardiovascular efficacy and safety of incretin-based therapies, testosterone or estrogen supplementation needs to be prudently evaluated in large-scale clinical studies. In this review, we briefly discuss the therapeutic effects of several key hormones in CHF.<\/jats:p>","DOI":"10.1177\/0300060518761262","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T07:50:57Z","timestamp":1519285857000},"page":"2063-2081","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Hormone treatments in congestive heart failure"],"prefix":"10.1177","volume":"46","author":[{"given":"Lei","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Aerospace Center Hospital, Peking University Affiliate, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Mao","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, 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