{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:35Z","timestamp":1777727135681,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701594"],"award-info":[{"award-number":["81701594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the clinical characteristics of infectious ulceration over tophi in patients with gout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were recruited from the First Affiliated Hospital of Wenzhou Medical University. The clinical characteristics of the patients and wound characteristics were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 38 enrolled patients, 18 were found to have infectious ulceration over tophi. Staphylococcus aureus was the most common pathogen and was identified in nine patients. Patients with infection were significantly older (69.6 vs. 60.1 years) and had a worse quality of life than those without infection. Patients with infection also had a significantly longer ulcer duration (125.6 vs. 54.2 days), larger ulcer size (2.47 vs. 1.99 cm\n                      <jats:sup>2<\/jats:sup>\n                      ), a higher rate of tissue necrosis in the ulcer bed (55.6% vs. 20.0%), a lower rate of callus at the edge (27.8% vs. 70.0%), and a higher moisture level than did patients without infection. Additionally, patients with infection had significantly delayed wound healing (35.3 vs. 20.3 days) compared with patients without infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older patients with a long ulcer duration and larger ulcer size are more susceptible to infection. Infection can lower patients\u2019 quality of life and delay wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518761303","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:16:48Z","timestamp":1522196208000},"page":"2258-2264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical characteristics of infectious ulceration over tophi in patients with gout"],"prefix":"10.1177","volume":"46","author":[{"given":"Jianjun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Burns, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wenzhou Central Hospital, Wenzhou 325000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"bibr1-0300060518761303","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60883-7"},{"key":"bibr2-0300060518761303","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep306"},{"key":"bibr3-0300060518761303","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-10-117"},{"key":"bibr4-0300060518761303","first-page":"U109","volume":"115","author":"Kumar S","year":"2002","journal-title":"N Z Med 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