{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:41Z","timestamp":1777727141749,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed compare the effectiveness of oxycodone and fentanyl in reducing the incidence and severity of etomidate-induced myoclonus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 162 patients with an American Society of Anesthesiologists physical status of I or II were assigned at random to three groups. Patients assigned to Group O received 0.1 mg\/kg of oxycodone (n\u2009=\u200954), those assigned to Group F were given 1 \u00b5g\/kg of fentanyl (n\u2009=\u200954), and those assigned to Group S were given an equal volume of saline intravenously 2 minutes prior to administration of 0.3 mg\/kg of etomidate (n\u2009=\u200954). The incidence and severity of myoclonus was evaluated 2 minutes after etomidate administration. The patients\u2019 vital signs, coughing, nausea, dizziness, and other related adverse reactions were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of myoclonus was significantly lower in Group O (0.0%) than in Group F (31.5%) and Group S (72.2%); the intensity was also lowest in Group O. All patients in each group had stable cardiovascular profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravenous injection of 0.1 mg\/kg of oxycodone 2 minutes prior to etomidate is more effective in preventing etomidate-induced myoclonus during general anesthesia than is 1\u2009\u00b5g\/kg of fentanyl.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518761788","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T07:48:53Z","timestamp":1521013733000},"page":"1839-1845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Oxycodone for prevention of etomidate-induced myoclonus: a randomized double-blind controlled trial"],"prefix":"10.1177","volume":"46","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyou","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"bibr1-0300060518761788","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2016.02.010"},{"key":"bibr2-0300060518761788","first-page":"143","volume":"11","author":"Kosarek L","year":"2011","journal-title":"Ochsner 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