{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:32Z","timestamp":1777727192313,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T00:00:00Z","timestamp":1526774400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Special Fund for Scientific and Technological Cooperation of Hainan, China","award":["KJHZ2015-28"],"award-info":[{"award-number":["KJHZ2015-28"]}]},{"name":"the Hainan provincial key scientific and technological research and development projects","award":["ZDYF2016158"],"award-info":[{"award-number":["ZDYF2016158"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate peripheral cytopenia in patients with splenomegaly due to hepatitis B-related cirrhotic portal hypertension (HBRCPH) by comparing blood cell counts from enlarged spleens with peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study involved patients undergoing splenectomy at the Nangfang Hospital from June 2013 to December 2015. Blood cell counts from peripheral blood were compared with those from splenic blood taken during splenectomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical data were available from 30 patients. White blood cell (WBC), red blood cell (RBC) and platelet counts were statistically significantly lower in peripheral blood compared with splenic blood. After splenectomy, peripheral blood cell counts increased significantly compared with pre-operative levels. Platelet and WBC counts in the lower spleen were significantly higher than those in the porta lienis (middle segment) and upper spleen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with splenomegaly due to HBRCPH, the counts of three blood cell lineages were significantly higher in the spleen than in peripheral blood. Splenectomy can aid the return of peripheral blood cell counts to normal levels. The most significant retention of platelets and WBCs occurred in the lower spleen which may be useful information for surgeons performing partial splenectomies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518767550","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T02:00:19Z","timestamp":1526868019000},"page":"2633-2640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Distribution characteristics of cells in splenomegaly due to hepatitis B-related cirrhotic portal hypertension and their clinical importance"],"prefix":"10.1177","volume":"46","author":[{"given":"Xiaoyu","family":"Han","sequence":"first","affiliation":[{"name":"Department of Liver Vascular Surgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfu","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan Provincial People\u2019s Hospital, Haikou 570311, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Reproductive, Maternal and Child Care of Hainan Province, Haikou 571000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan Provincial People\u2019s Hospital, Haikou 570311, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan Provincial People\u2019s Hospital, Haikou 570311, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Liver Vascular Surgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan Provincial People\u2019s Hospital, Haikou 570311, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixian","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Liver Vascular Surgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, 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