{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:44Z","timestamp":1777727204881,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004204","name":"Tongji University","doi-asserted-by":"publisher","award":["2016KJ052"],"award-info":[{"award-number":["2016KJ052"]}],"id":[{"id":"10.13039\/501100004204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute coronary syndrome (ACS) is associated with several clinical syndromes, one of which is acute non-ST-segment ACS (NSTE-ACS). S100A1 is a calcium-dependent regulator of heart contraction and relaxation. We investigated the association between the serum S100A1 level and the Global Registry of Acute Coronary Events (GRACE) risk score in patients with NSTE-ACS and the potential of using the serum S100A1 level to predict the 30-day prognosis of NSTE-ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical characteristics of 162 patients with NSTE-ACS were analyzed to determine the GRACE score. The serum S100A1 concentration was determined using fasting antecubital venous blood. The patients were divided into different groups according to the serum S100A1 level, and the 30-day NSTE-ACS prognosis was evaluated using Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum S100A1 levels differed significantly among the groups. Correlation analysis showed that the serum S100A1 level was positively correlated with the GRACE score. Kaplan\u2013Meier analysis revealed that the number of 30-day cardiac events was significantly higher in patients with an S100A1 level of &gt;3.41 ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>S100A1 is a potential biomarker that can predict the progression of NSTE-ACS and aid in its early risk stratification and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518769524","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T07:07:02Z","timestamp":1526368022000},"page":"2670-2678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between serum S100A1 level and Global Registry of Acute Coronary Events score in patients with non-ST-segment elevation acute coronary syndrome"],"prefix":"10.1177","volume":"46","author":[{"given":"Yuanmin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangfu","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"bibr1-0300060518769524","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"bibr2-0300060518769524","doi-asserted-by":"publisher","DOI":"10.1159\/000364996"},{"key":"bibr3-0300060518769524","first-page":"63","volume":"10","author":"Borden WB","year":"2009","journal-title":"Rev Cardiovasc 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