{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:15:54Z","timestamp":1788207354402,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["144202 and 310030_166357\/1"],"award-info":[{"award-number":["144202 and 310030_166357\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010765","name":"Swiss Dental Association","doi-asserted-by":"crossref","award":["259"],"award-info":[{"award-number":["259"]}],"id":[{"id":"10.13039\/100010765","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed to explore the expression of \u03b1-smooth muscle actin (\u03b1-SMA) in the periodontal ligament (PDL) of young and adult rats during post-emergent tooth eruption in opposed and unopposed teeth at two time points: 3 and 15 days after antagonist loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four-week-old (n\u2009=\u200920) and 22-week-old (n\u2009=\u200920) male Wistar rats were used. The right maxillary molar crowns were cut down. PDL samples were isolated from the first mandibular molars at two time points: 3 and 15 days after cut-down of the right maxillary molars. Quantitative reverse-transcription polymerase chain reaction and immunohistochemical staining were performed to detect differences in \u03b1-SMA expression in the PDL tissues of unopposed versus opposed molars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u03b1-SMA was upregulated in the PDL of the unopposed molars in the 3-day group of young rats. The region around the root apex of the unopposed molars in this group exhibited strong immunostaining for \u03b1-SMA. The expression level and immunoreactivity of \u03b1-SMA did not differ in both time points in young controls and among all the adult groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03b1-SMA-positive myofibroblasts are implicated in post-emergent tooth eruption of unopposed molars of young animals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518769545","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T08:47:41Z","timestamp":1529484461000},"page":"2423-2435","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression of \u03b1-smooth muscle actin in the periodontal ligament during post-emergent tooth eruption"],"prefix":"10.1177","volume":"46","author":[{"given":"Domna","family":"Dorotheou","sequence":"first","affiliation":[{"name":"Department of Orthodontics, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luce","family":"Bochaton-Piallat","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Giannopoulou","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Kiliaridis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"bibr1-0300060518769545","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700509"},{"key":"bibr2-0300060518769545","first-page":"480","volume":"13","author":"Kiliaridis S","year":"2000","journal-title":"Int J 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