{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:10:15Z","timestamp":1778541015508,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Jilin Province Broadwell Pharmaceutical Co., Ltd.,Changchun,China","award":["2016-02-03"],"award-info":[{"award-number":["2016-02-03"]}]},{"name":"Technology Innovation Fund for Enterprises","award":["2017-001-FW"],"award-info":[{"award-number":["2017-001-FW"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of polaprezinc (PZ) on cyclophosphamide (CTX)- or cisplatin (DDP)-induced gastric mucosal injury and on a rat model of neurotransmitter-mediated vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sprague\u2013Dawley rats were divided at random into Control, CTX, DDP, PZ+CTX, and PZ+DDP groups. After 20 days, brain tissues and sera were analyzed for the levels of dopamine (DA), 5-hydroxytryptamine (5-HT), and nuclear factor kappa B (NF-\u03baB). Hematoxylin and eosin-stained sections of stomach, intestine, and brain tissues were examined using light microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of DA, 5-HT, and NF-\u03baB in brain and serum samples of rats treated with CTX or DDP were significantly increased compared with those of rats in the Control group. There was a significant decrease in these values in the PZ group. Moreover, PZ reduced damage to brain tissue caused by CTX or DDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PZ decreased the levels of DA, 5-HT, and NF-\u03baB in blood and brain tissues caused by CTX or DDP and reduced the chemotherapy-induced damage to the small intestine, stomach, and brain. These findings can be translated to the clinic to enhance the efficacy and safety of chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518771492","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T02:49:09Z","timestamp":1526266149000},"page":"2436-2444","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of polaprezinc on gastric mucosal damage and neurotransmitters in a rat model of chemotherapy-induced vomiting"],"prefix":"10.1177","volume":"46","author":[{"given":"Zhao Yang","family":"Liu","sequence":"first","affiliation":[{"name":"National Cancer Center\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Bo","family":"Xie","sequence":"additional","affiliation":[{"name":"Jilin Province Broadwell Pharmaceutical Co., Ltd., Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ru Li","sequence":"additional","affiliation":[{"name":"Jilin Province Broadwell Pharmaceutical Co., Ltd., Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Teng","sequence":"additional","affiliation":[{"name":"Jilin Province Broadwell Pharmaceutical Co., Ltd., Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 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