{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:08:41Z","timestamp":1777727321005,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Jiangxi provincial education Bureau for the research of science and technology","award":["GJJ151472"],"award-info":[{"award-number":["GJJ151472"]}]},{"name":"the Nanchang Science and Technology Bureau for the Promotion of Science","award":["2014SFZC009"],"award-info":[{"award-number":["2014SFZC009"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between inflammatory factors, oxidative stress and type 1 deiodinase (DIO-1) concentration in patients with chronic renal failure (CRF) with or without euthyroid sick syndrome (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study recruited patients with CRF and divided them into two groups: group 1 had low free triiodothyronine (FT3) levels; and group 2 had normal FT3 levels. Group 3 consisted of healthy volunteers. Serum levels of interleukin (IL)-6, IL-1\u03b2, tumour necrosis factor (TNF)-\u03b1, 8-isoprostane and DIO-1 were measured using enzyme-linked immunosorbent assays. Multiple regression analysis was used to analyse correlations between parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty patients were enrolled into each group and the groups were comparable in terms of vital signs, white blood cell count, free thyroxine and thyroid stimulating hormone concentrations. The serum DIO-1 concentration was significantly higher in group 2 than in groups 1 and 3. Multivariate regression analysis revealed that the DIO-1 concentration was inversely correlated with the TNF-\u03b1 concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with CRF without ESS showed higher concentrations of DIO-1 than patients with ESS. The DIO-1 concentration was inversely correlated with the TNF-\u03b1 concentration, which might indicate that the inflammatory response was milder in the patients with CRF without ESS than in those with ESS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518778190","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T08:07:10Z","timestamp":1535443630000},"page":"4061-4070","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-2833","authenticated-orcid":false,"given":"Shu-Lan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Experimental Centre, Jiangxi Health Vocational College, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Cheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Aimee","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Experimental Centre, Jiangxi Health Vocational College, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Fang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Experimental Centre, Jiangxi Health Vocational College, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Feng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, 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