{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:21:53Z","timestamp":1778073713794,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed to systematically compare the safety and efficacy of total enteral nutrition (TEN) and total parenteral nutrition (TPN) for patients with severe acute pancreatitis (SAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed database was searched up to January 2017, and nine studies were retrieved. These studies were selected according to specific eligibility criteria. The methodological quality of each trial was assessed, and the study design, interventions, participant characteristics, and final results were then analyzed by Review Manager 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine relevant randomized controlled trials involving 500 patients (244 patients in the TEN group and 256 patients in the TPN group) were included in the meta-analysis. Pooled analysis showed a significantly lower mortality rate in the TEN than TPN group [odds ratio (OR), 0.31; 95% confidence interval (CI), 0.18\u20130.54]. The duration of hospitalization was significantly shorter in the TEN than TPN group (mean difference, \u22120.59; 95% CI, \u22122.56\u20131.38). Compared with TPN, TEN had a lower risk of pancreatic infection and related complications (OR, 0.41; 95% CI, 0.22\u20130.77), organ failure (OR, 0.17; 95% CI, 0.06\u20130.52), and surgical intervention (OR, 0.17; 95% CI, 0.05\u20130.62).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis indicates that TEN is safer and more effective than TPN for patients with SAP. When both TEN and TPN have a role in the management of SAP, TEN is the preferred option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518782070","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T02:59:47Z","timestamp":1530500387000},"page":"3948-3958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Safety and efficacy of total parenteral nutrition versus total enteral nutrition for patients with severe acute pancreatitis: a meta-analysis"],"prefix":"10.1177","volume":"46","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgical Intensive Care Unit, China-Japan Friendship Hospital, Yinghuadongjie, Chaoyang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, China-Japan Friendship Hospital, Yinghuadongjie, Chaoyang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei province 050011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, China-Japan Friendship Hospital, Yinghuadongjie, Chaoyang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,1]]},"reference":[{"key":"bibr1-0300060518782070","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0889-8553(21)00640-3","volume":"18","author":"Havala T","year":"1989","journal-title":"Gastroenterol Clin North Am"},{"key":"bibr2-0300060518782070","first-page":"275","volume":"175","author":"Pisters PW","year":"1992","journal-title":"Surg Gynecol Obstet"},{"key":"bibr3-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90157-3"},{"key":"bibr4-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1991.10718140"},{"key":"bibr5-0300060518782070","first-page":"516","volume":"116","author":"Kudsk KA","year":"1994","journal-title":"Surgery"},{"key":"bibr6-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199208000-00008"},{"key":"bibr7-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.431"},{"key":"bibr8-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01558.x"},{"key":"bibr9-0300060518782070","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082007000500004"},{"key":"bibr10-0300060518782070","first-page":"157","volume":"10","author":"Doley RP","year":"2009","journal-title":"JOP"},{"key":"bibr11-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000246866.01930.58"},{"key":"bibr12-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1159\/000073657"},{"key":"bibr13-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800841207"},{"key":"bibr14-0300060518782070","first-page":"298","volume":"48","author":"Louie BE","year":"2005","journal-title":"Can J Surg"},{"key":"bibr15-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1159\/000097949"},{"key":"bibr16-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.12.010"},{"key":"bibr17-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181bd6370"},{"key":"bibr18-0300060518782070","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.326.11278"},{"key":"bibr19-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/83.8.713"},{"key":"bibr20-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.015015"},{"key":"bibr21-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70011-X"},{"key":"bibr22-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.03.022"},{"key":"bibr23-0300060518782070","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6685"},{"key":"bibr24-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1159\/000189382"},{"issue":"1","key":"bibr25-0300060518782070","first-page":"CD002837","author":"Al-Omran M","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr26-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199105000-00009"},{"key":"bibr27-0300060518782070","first-page":"CD002837","volume":"1","author":"Al-Omran M","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr28-0300060518782070","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(99)80067-5"},{"key":"bibr29-0300060518782070","unstructured":"Helton WS. 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