{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:56Z","timestamp":1777727396983,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed to determine the healing effects of pentoxifylline on molecular responses and protection against severe ischemic damage in the small intestine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty-six Wistar albino rats were divided into six groups. The superior mesenteric artery was clamped for 120 minutes, and reperfusion was performed for 60 minutes. Saline (0.4\u2009mL), pentoxifylline (1\u2009mg\/kg), and pentoxifylline (10\u2009mg\/kg) were intraperitoneally administered to the rats in the C\n                      <jats:sub>1<\/jats:sub>\n                      , P\n                      <jats:sub>1<\/jats:sub>\n                      , and P\n                      <jats:sub>3<\/jats:sub>\n                      groups, respectively, 60 minutes before ischemia and to the rats in the C\n                      <jats:sub>2<\/jats:sub>\n                      , P\n                      <jats:sub>2<\/jats:sub>\n                      , and P\n                      <jats:sub>4<\/jats:sub>\n                      groups, respectively, during reperfusion onset. Malondialdehyde, myeloperoxidase, tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in serum and tissue were measured by enzyme-linked immunosorbent assay. Intestinal ischemic injury was histopathologically evaluated by the Chiu score and immunohistochemical staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All serum and tissue molecular responses were significantly blunted in the pentoxifylline-treated groups compared with the controls. Significant improvement in ischemic damage was demonstrated in the pentoxifylline-treated groups by histological grading and immunohistochemical scoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The protective effects of pentoxifylline were confirmed by molecular responses and histopathological examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518786904","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T07:18:06Z","timestamp":1532071086000},"page":"4140-4156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective effects of pentoxifylline in small intestine after ischemia\u2013reperfusion"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-5205","authenticated-orcid":false,"given":"Seracettin","family":"E\u011fin","sequence":"first","affiliation":[{"name":"Sa\u011fl\u0131k Bilimleri Universitesi, General Surgery, Okmeydan\u0131 Education and Research Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"Istanbul Universitesi Istanbul T\u0131p Fakultesi, General Surgery, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Bademler","sequence":"additional","affiliation":[{"name":"Istanbul Universitesi Istanbul T\u0131p Fakultesi, General Surgery, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berk","family":"G\u00f6k\u00e7ek","sequence":"additional","affiliation":[{"name":"Sa\u011fl\u0131k 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