{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:10:30Z","timestamp":1777727430803,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Nature Science Fund from China","award":["81471515"],"award-info":[{"award-number":["81471515"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report a case of abortion after intracytoplasmic sperm injection (ICSI) with ejaculated spermatozoa obtained from a man with mosaic Klinefelter\u2019s syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sperm nuclei from the patient were analyzed by fluorescence in situ hybridization, and the disomy frequencies for chromosome 18 and the sex chromosomes were determined. A literature review of the ICSI outcome of ejaculated sperm in patients with Klinefelter\u2019s syndrome was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 108 spermatozoa nuclei were analyzed. Of these, 102 sperm cells were normal with an X18 (55.56%) or Y18 (38.89%) chromosome pattern. Three cells with XX18 (2.78%) and three cells with YY18 (2.78%) signals were detected. The fetus stopped developing in the eighth week. The karyotype determined by an analysis of the abortive tissue was 46, XY. The literature review identified a total of 12 patients who were analyzed in 11 reports. The fertilization rate was 80.9%, and the live birth rate per transfer was 71.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ICSI with ejaculated spermatozoa from men with Klinefelter\u2019s syndrome can lead to pregnancy, for which the risk of transmission of chromosomal aneuploidy is low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518788757","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T01:32:00Z","timestamp":1533000720000},"page":"4323-4331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Intracytoplasmic sperm injection outcome of ejaculated spermatozoa from a man with mosaic Klinefelter's Syndrome: case report and literature review"],"prefix":"10.1177","volume":"46","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xi","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jili","family":"Jing","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, the First Hospital, Jilin University, Changchun, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"bibr1-0300060518788757","first-page":"9","volume-title":"Aneuploidy: Incidence and etiology","author":"Hecht F","year":"1987"},{"key":"bibr2-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137315"},{"key":"bibr3-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1016\/j.anngen.2003.08.024"},{"key":"bibr4-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"bibr5-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00231.x"},{"key":"bibr6-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2322"},{"key":"bibr7-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.11.2447"},{"key":"bibr8-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1909"},{"key":"bibr9-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.2.107"},{"key":"bibr10-0300060518788757","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.4.1014"},{"key":"bibr11-0300060518788757","first-page":"609","volume":"12","author":"Haibo Z","year":"2014","journal-title":"Iran J Reprod Med"},{"key":"bibr12-0300060518788757","unstructured":"Brinsden PR. 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