{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:53:22Z","timestamp":1790070802715,"version":"4.0.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A patent foramen ovale (PFO) is detected frequently by echocardiography. However, a thrombus trapped in a PFO is relatively rare. We herein describe a rare case of a 51-year-old patient with pulmonary embolism in which a large thrombus-in-transit through a PFO was found by echocardiography and disappeared after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 51-year-old woman presented with a 1-week history of chest tightness, unspecified chest pain, and shortness of breath. Echocardiography revealed a large thrombus trapped in a PFO with increased pulmonary artery pressure, which is a very rare and critical condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient was treated with thrombolysis and anticoagulation and discharged from the hospital with an uneventful recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our treatment of the present patient achieved a satisfactory result, but it may not be applicable to every patient. Echocardiography is a readily available and safe tool for demonstrating the size, location, and extent of a thrombus, and it plays an important role in the early diagnosis and treatment evaluation for patients with a thrombus trapped in a PFO with concurrent pulmonary embolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518789820","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T08:24:25Z","timestamp":1533716665000},"page":"4332-4337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Large thrombus-in-transit within a patent foramen ovale in a patient with pulmonary embolism: a case report"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-6360","authenticated-orcid":false,"given":"Changhong","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Qingdao University Affiliated Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wugang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Qingdao University Affiliated Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Qingdao University Affiliated Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Qingdao University Affiliated Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Qingdao University Affiliated Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"bibr1-0300060518789820","first-page":"6752709","volume":"2017","author":"Shepherd F","year":"2017","journal-title":"Case Rep Cardiol"},{"key":"bibr2-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.066"},{"key":"bibr3-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2010.01168.x"},{"key":"bibr4-0300060518789820","doi-asserted-by":"crossref","first-page":"690","DOI":"10.20452\/pamw.3059","volume":"125","author":"Urszula AS","year":"2015","journal-title":"Pol Arch Med Wewn"},{"key":"bibr5-0300060518789820","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2015.68.1.70"},{"key":"bibr6-0300060518789820","first-page":"K47","volume":"4","author":"Ellensen VS","year":"2017","journal-title":"Echo Res Pract"},{"key":"bibr7-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.05.015"},{"key":"bibr8-0300060518789820","volume":"16","author":"Hui DS","year":"2016","journal-title":"Ochsner J"},{"key":"bibr9-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0961"},{"key":"bibr10-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.11.007"},{"key":"bibr11-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.07.039"},{"key":"bibr12-0300060518789820","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3.806"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518789820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060518789820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518789820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:25Z","timestamp":1777459765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060518789820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,8]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1177\/0300060518789820"],"URL":"https:\/\/doi.org\/10.1177\/0300060518789820","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,8]]}}}