{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:10:44Z","timestamp":1777727444993,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok","award":["(N\/ST\/ZB\/16\/004\/1145)"],"award-info":[{"award-number":["(N\/ST\/ZB\/16\/004\/1145)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed to assess the effect of a single dose of 15% mannitol on the hydration status and electrolyte balance in patients with tick-borne encephalitis (TBE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-one patients with TBE were treated with 0.25 g\/kg of 15% mannitol. The electrolyte concentrations (Na, K, and Cl), creatinine concentration, and hydration status were measured before and after mannitol infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After mannitol administration, 7 patients had hyponatremia, 3 had hypokalemia, 1 had hyperkalemia, and 17 had hypochloremia. The total body water volume (TBW) changed by 0.44%\u2009\u00b1\u20090.55%, the external body water volume (EBW) changed by 0.12%\u2009\u00b1\u20090.15%, and the internal body water volume (IBW) changed by 0.19%\u2009\u00b1\u20090.40%. The mean ECW\/ICW ratio was 0.7694\u2009\u00b1\u20090.07 before treatment and 0.7699\u2009\u00b1\u20090.07 after treatment. Age was correlated with the TBW change in men (R\u2009=\u20090.42, p\u2009&lt;\u20090.05) and with the potassium change in women (R\u2009=\u20090.66, p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with TBE should receive mannitol two to four times daily depending on the clinical manifestation. Administration of a single dose of mannitol (0.25 g\/kg) requires at least 300\u2009mL of fluid supplementation. Bioimpedance might be useful for individual evaluation of dehydration. Additionally, patients require monitoring for potential hyponatremia. Older men may be more prone to dehydration after receiving mannitol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518790175","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T08:42:31Z","timestamp":1534754551000},"page":"5083-5089","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of a single dose of mannitol on hydration status and electrolyte concentrations in patients with tick-borne encephalitis"],"prefix":"10.1177","volume":"46","author":[{"given":"Piotr","family":"Czupryna","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Moniuszko-Malinowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambor","family":"Grygorczuk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Pancewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Dunaj","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Borawski","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Zajkowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University of Bia\u0142ystok, Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"bibr1-0300060518790175","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106199"},{"issue":"1","key":"bibr2-0300060518790175","first-page":"S37","volume":"49","author":"Dennis LJ","year":"2001","journal-title":"Neurol 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