{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:15:01Z","timestamp":1785795301984,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Von Hippel-Lindau (VHL) syndrome is caused by germline mutations in the\n                    <jats:italic toggle=\"yes\">VHL<\/jats:italic>\n                    gene and is accompanied by the development of both benign and malignant tumors. Clarithromycin (CAM) is a widely used anti-inflammatory drug that has also been proven effective for treating some cancers. In this study, we present a novel case of a 38-year-old female patient with VHL syndrome confirmed by computed tomography, with no relevant family history. The patient was only offered close follow-up observation after diagnosis, but was orally administered CAM twice daily when her disease progressed. After treatment for 3 months, her inner ear tumors had stopped growing and her kidney cysts had shrunk. Her pancreatic tumors treated with CAM showed no significant increase in size, and the lymph node swelling disappeared. CAM treatment was interrupted for 2 years and then stopped for 5 years when improvements were noted; the patient\u2019s condition thereafter gradually improved and finally stabilized with no obvious side effects. We discuss this case in the context of the published literature and consider the possible mechanisms of CAM action in the treatment of VHL syndrome. To our knowledge, this is the first case report of a patient with VHL syndrome treated with CAM.\n                  <\/jats:p>","DOI":"10.1177\/0300060518792368","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:37:55Z","timestamp":1536050275000},"page":"973-981","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of clarithromycin in von Hippel-Lindau syndrome: a case report"],"prefix":"10.1177","volume":"47","author":[{"given":"Xin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.01.040"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493574"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11 <2478::AID-CNCR4>3.0.CO;2-5"},{"key":"e_1_3_3_5_2","first-page":"474","article-title":"Comparison of the anti-angiogenic and anti-inflammatory effects of two antibiotics: clarithromycin versus moxifloxacin.","volume":"41","author":"Uehara H","year":"2015","unstructured":"Uehara H, Das SK, Cho YK, et\u00a0al. Comparison of the anti-angiogenic and anti-inflammatory effects of two antibiotics: clarithromycin versus moxifloxacin. Curr Eye Res 2015; 41: 474\u2013484.","journal-title":"Curr Eye Res"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000239580"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048556"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041883"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.08.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.90"},{"key":"e_1_3_3_11_2","article-title":"Inhibitive effects of clarithromycin on corneal neovascularization induced by alkali burn","author":"Huang XP","year":"2008","unstructured":"Huang XP, Pang DB. Inhibitive effects of clarithromycin on corneal neovascularization induced by alkali burn. Recent Advances in Ophthalmology 2008.","journal-title":"Recent Advances in Ophthalmology"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2002.17.4.211"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004330050068"},{"key":"e_1_3_3_14_2","first-page":"2259","article-title":"Effect of clarithromycin treatment on natural killer cell activity in patients with advanced non-small cell lung cancer.","volume":"25","author":"Sakamoto M","year":"1998","unstructured":"Sakamoto M, Mikasa K, Majima T, et\u00a0al. Effect of clarithromycin treatment on natural killer cell activity in patients with advanced non-small cell lung cancer. Gan to Kagaku Ryoho 1998; 25: 2259\u20132266[in Japanese, English Abstract].","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000098426"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13643-4"},{"key":"e_1_3_3_17_2","first-page":"5","article-title":"Familial and genetic study in a large Chinese kindred with von Hippel-Lindau disease and gene mutation analysis","volume":"21","author":"Zhang J","year":"2004","unstructured":"Zhang J, Huang YR, Wang JD, et\u00a0al. [ Familial and genetic study in a large Chinese kindred with von Hippel-Lindau disease and gene mutation analysis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004; 21: 5\u20139[in Chinese, English Abstract].","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"e_1_3_3_18_2","first-page":"505","article-title":"Von Hippel-Lindau disease: protocols for diagnosis and periodical clinical monitoring. national Von Hippel-Lindau disease working group","volume":"144","author":"Hes FJ","year":"2000","unstructured":"Hes FJ and van der Luijt RB. [ Von Hippel-Lindau disease: protocols for diagnosis and periodical clinical monitoring. national Von Hippel-Lindau disease working group]. Ned Tijdschr Geneeskd 2000; 144: 505\u2013509[in Dutch, English Abstract].","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_3_3_19_2","first-page":"521","article-title":"Genetic analysis of von Hippel-Lindau disease.","volume":"31","author":"Nordstrom-O'Brien M","year":"2010","unstructured":"Nordstrom-O'Brien M, van der Luijt RB, van Rooijen E, et\u00a0al. Genetic analysis of von Hippel-Lindau disease. Hum Mutat 2010; 31: 521\u2013537.","journal-title":"Hum Mutat"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10050971"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00078-09"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.2017.88"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh265"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25134"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084256"},{"key":"e_1_3_3_27_2","first-page":"223","article-title":"Affection of clarithromycin on the expressions of MMP-9 and VEGF in lung cancer cells]","volume":"23","author":"Bai C","year":"2002","unstructured":"Bai C, Liu W, Qi H. [ Affection of clarithromycin on the expressions of MMP-9 and VEGF in lung cancer cells]. Journal of Xi'an Medical University 2002; 23: 223\u2013226[in Chinese].","journal-title":"Journal of Xi'an Medical University"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518792368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060518792368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518792368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:35Z","timestamp":1777459775000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060518792368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0300060518792368"],"URL":"https:\/\/doi.org\/10.1177\/0300060518792368","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,4]]}}}