{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:02:37Z","timestamp":1785150157252,"version":"3.55.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis was performed to evaluate the effect of spinal anesthesia (SA) using bupivacaine combined with dexmedetomidine (DEX) in cesarean section, analyze the adverse drug reactions induced by this mixture, and provide a reference for rational drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials were obtained from the PubMed, Cochrane Library, and Embase databases. The primary outcome measure was the time to the highest sensory block level (min), and the secondary outcome measure was adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The time to the highest sensory block level was significantly shorter in the bupivacaine-DEX group than in the control group (standardized mean difference, \u22120.23; 95% confidence interval, \u22120.43 to \u22120.03). The incidence of shivering during the process of anesthesia, especially at a dose of 5 \u00b5g DEX, was significantly lower in the bupivacaine-DEX group than in the control group (odds ratio, 0.26; 95% confidence interval, 0.14\u20130.49). No significant differences were observed in the symptoms of hypotension, bradycardia, nausea\/vomiting, or pruritus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with the use of bupivacaine alone for SA in cesarean section, adding dexmedetomidine during SA can significantly shorten the onset time and decrease the rate of shivering during anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518797000","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T05:23:00Z","timestamp":1560748980000},"page":"2785-2799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative evaluation of intrathecal bupivacaine alone and bupivacaine combined with dexmedetomidine in cesarean section using spinal anesthesia: a meta-analysis"],"prefix":"10.1177","volume":"47","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Hanchuan City People's Hospital, Hanchuan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery II, Hanchuan City People's Hospital, Hanchuan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.5(3)2015.22798"},{"issue":"3","key":"e_1_3_3_3_2","first-page":"CD004660","article-title":"Caesarean section for non-medical reasons at term","author":"Lavender T","year":"2012","unstructured":"Lavender T, Hofmeyr GJ, Neilson JP, et\u00a0al. 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