{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:13:24Z","timestamp":1777727604081,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Zhaoqing Science and Technology Innovation Guidance Project","award":["No. 201624030202"],"award-info":[{"award-number":["No. 201624030202"]}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["No. A2018498"],"award-info":[{"award-number":["No. A2018498"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of pre-injection of butorphanol on etomidate-induced myoclonus during anesthesia induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) of the ability of butorphanol to prevent etomidate-induced myoclonus were collected by searching PubMed, Cochrane Library, CNKI, and WanFang databases, from the day of database establishment until May 2017. The literature was screened independently by two evaluators, and the data were then extracted and independently evaluated. Finally, meta-analysis was performed by using RevMan 5.2 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight RCTs were analyzed. The results of meta-analysis showed that: 1. compared with the control group, butorphanol was effective in preventing etomidate-induced myoclonus [RR\u2009=\u20090.15, 95% CI: 0.11, 0.21]; 2. butorphanol was effective in preventing mild, moderate, and severe etomidate-induced myoclonus [RR\u2009=\u20090.40, 95% CI: 0.25, 0.63; RR\u2009=\u20090.15, 95% CI: 0.08, 0.27; and RR\u2009=\u20090.04, 95% CI: 0.01, 0.09]; 3. butorphanol did not increase the incidence of dizziness and nausea associated with etomidate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Butorphanol could reduce the incidence and degree of etomidate-induced myoclonus. Notably, it did not increase the incidence of dizziness and nausea associated with etomidate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518801457","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T04:10:20Z","timestamp":1543551020000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Butorphanol effectively prevents etomidate-induced myoclonus: a pooled analysis of 788 patients"],"prefix":"10.1177","volume":"47","author":[{"given":"Yu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Nursing, Zhaoqing Medical College, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengmao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Zhaoqing Medical College, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixiong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Zhaoqing Medical College, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,30]]},"reference":[{"key":"bibr1-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199901000-00017"},{"key":"bibr2-0300060518801457","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889833"},{"key":"bibr3-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010969"},{"key":"bibr4-0300060518801457","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2011.61.2.127"},{"key":"bibr5-0300060518801457","doi-asserted-by":"crossref","first-page":"w14042","DOI":"10.4414\/smw.2014.14042","volume":"144","author":"He L","year":"2014","journal-title":"Swiss Med Wkly"},{"key":"bibr6-0300060518801457","first-page":"1325","volume":"35","author":"Zhang J","year":"2015","journal-title":"Chin J Anesthesiol"},{"key":"bibr7-0300060518801457","first-page":"3731","volume":"12","author":"Wang B.","year":"2015","journal-title":"Laboratory Medicine and Clinic"},{"key":"bibr8-0300060518801457","first-page":"280","volume":"28","author":"Zhao X","year":"2008","journal-title":"Chin J Anesthesiol"},{"key":"bibr9-0300060518801457","first-page":"58","volume":"53","author":"Ren J","year":"2013","journal-title":"Shandong Medical Journal"},{"key":"bibr10-0300060518801457","first-page":"1450","volume":"43","author":"Jing Z","year":"2015","journal-title":"Tianjin Medical Journal"},{"key":"bibr11-0300060518801457","first-page":"510","volume":"29","author":"Xu P","year":"2013","journal-title":"Journal of Clinical Anesthesiology"},{"key":"bibr12-0300060518801457","first-page":"32","volume":"12","author":"Run Z","year":"2015","journal-title":"Medical Innovation of China"},{"key":"bibr13-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181852595"},{"key":"bibr14-0300060518801457","first-page":"144","volume":"11","author":"Wang X","year":"1991","journal-title":"Chin J Anesthesiol"},{"key":"bibr15-0300060518801457","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S137464"},{"key":"bibr16-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.09.008"},{"key":"bibr17-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ05001X"},{"key":"bibr18-0300060518801457","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)01004-3"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518801457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060518801457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518801457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:52Z","timestamp":1777459792000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060518801457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,30]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/0300060518801457"],"URL":"https:\/\/doi.org\/10.1177\/0300060518801457","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,30]]}}}