{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:14:07Z","timestamp":1777727647406,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. pneumoniae<\/jats:italic>\n                      have been demonstrated in patients with reactive arthritis. Both of these microorganisms can cause chronic and persistent infections, with\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      being the most common cause of reactive arthritis. This study was performed to investigate the presence of\n                      <jats:italic toggle=\"yes\">C. pneumoniae<\/jats:italic>\n                      in a large number of patients with primary OA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included 75 patients who underwent total knee arthroplasty. During surgery, a synovial biopsy was performed and synovial fluid drawn. Real-time polymerase chain reaction (PCR) of\n                      <jats:italic toggle=\"yes\">C. pneumoniae<\/jats:italic>\n                      was run on all patients, and real-time PCR of bacterial 16S rDNA was conducted on 30 of the 75 patients to screen for the presence of other bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Real-time PCR showed no evidence of the presence of\n                      <jats:italic toggle=\"yes\">C. pneumoniae<\/jats:italic>\n                      in the patients\u2019 specimens, nor were other bacteria detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although an inflammatory component is part of the pathogenesis of OA, we found no evidence indicating that\n                      <jats:italic toggle=\"yes\">C. pneumoniae<\/jats:italic>\n                      is a stimulator of that inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518807062","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:01:01Z","timestamp":1541390461000},"page":"635-640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["No evidence of\n                    <i>Chlamydia pneumoniae<\/i>\n                    in the synovia of patients with osteoarthritis"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-9190","authenticated-orcid":false,"given":"Marie","family":"Edvinsson","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Welvaart","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Ryttberg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Wretenberg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Vikerfors","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u00d6rebro University, \u00d6rebro, Sweden"},{"name":"V\u00e4ster\u00e5s Central Hospital, V\u00e4ster\u00e5s, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Nystr\u00f6m-Rosander","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-2088-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4934"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920208786847953"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12467868"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.05.001"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.2.100"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/315596"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1174"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2000.0360"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27394"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2273-2274.2002"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600617058"},{"key":"e_1_3_4_14_2","first-page":"12","volume-title":"Interpretive Criteria for Identification of Bacteria and Fungi by DNA Target Sequencing; Approved guideline. MM18A","author":"Petti CA","year":"2008","unstructured":"Petti CA, Bosshard PP, Brandt ME, et\u00a0al. Interpretive Criteria for Identification of Bacteria and Fungi by DNA Target Sequencing; Approved guideline. MM18A. Vol. 28. Wayne, Pennsylvania, USA: Clinical and Laboratory Standards Institute, 2008, p.12."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-52-4-1263"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(98)00137-9"},{"key":"e_1_3_4_17_2","first-page":"1874","article-title":"Chlamydial nucleic acids in synovium in osteoarthritis: what are the implications?","volume":"28","author":"Olmez N","year":"2001","unstructured":"Olmez N, Wang GF, Li Y, et\u00a0al. Chlamydial nucleic acids in synovium in osteoarthritis: what are the implications? J Rheumatol 2001; 28: 1874\u20131880.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24431"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1460-z"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2217-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/515280"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200007000-00004"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1889::AID-ANR13>3.0.CO;2-W"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391018"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar382"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100169900277"},{"key":"e_1_3_4_27_2","first-page":"13","article-title":"What role do periodontal pathogens play in osteoarthritis and periprosthetic joint infections of the knee?","volume":"12","author":"Ehrlich GD","year":"2014","unstructured":"Ehrlich GD, Hu FZ, Sotereanos N, et\u00a0al. What role do periodontal pathogens play in osteoarthritis and periprosthetic joint infections of the knee? J Appl Biomater Funct Mater 2014; 12: 13\u201320.","journal-title":"J Appl Biomater Funct Mater"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3182500c95"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32830aba34"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/672395"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518807062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060518807062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518807062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:58Z","timestamp":1777459798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060518807062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0300060518807062"],"URL":"https:\/\/doi.org\/10.1177\/0300060518807062","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]}}}