{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:17Z","timestamp":1777727717873,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Many studies have shown that\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      ) is negatively correlated with gastroesophageal reflux disease (GERD). Moreover, some studies deny that eradication of\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      increases the incidence of GERD. Therefore, we investigated the association of\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      infection with GERD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective analysis, patients with peptic ulcers were used as a blank control group. We used logistic regression to analyze the relationship between\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      infection and GERD. We analyzed 953 patients with peptic ulcers, 180 patients with both peptic ulcers and GERD, and 298 patients with GERD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the patients with GERD, 75.6% (136\/180) and 36.2% (108\/298) of those with and without peptic ulcers, respectively, had\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      infection, and the difference was statistically significant. Among patients with peptic ulcers, 75.6% (136\/180) and 67.4% (642\/953) of those with and without GERD, respectively, had\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      infection. The incidence of GERD in patients with\n                      <jats:italic toggle=\"yes\">Hp-<\/jats:italic>\n                      positive and -negative peptic ulcers was 17.5% (136\/778) and 12.4% (44\/355), respectively. These differences were also statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In the analysis of patients with GERD, the prevalence of\n                      <jats:italic toggle=\"yes\">Hp<\/jats:italic>\n                      infection was higher among patients with than without peptic ulcers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518809871","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T01:10:58Z","timestamp":1542676258000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of\n                    <i>Helicobacter pylori<\/i>\n                    infection with gastroesophageal reflux disease"],"prefix":"10.1177","volume":"47","author":[{"given":"Wu","family":"Jie","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei Province, China"},{"name":"Medical College of Jianghan University, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Qinghong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei Province, China"},{"name":"Medical College of Jianghan University, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhitao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.443"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.08.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025840"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7392.737"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.029"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12370"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70024-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000085"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.734"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04894-7"},{"key":"e_1_3_2_13_2","first-page":"153","article-title":"Helicobacter pylori infection and gastroesophageal reflux disease - Barrett's esophagus sequence \u201cdilemma","volume":"28","author":"Kountouras J","year":"2015","unstructured":"Kountouras J, Zavos C, Polyzos SA, et\u00a0al. Helicobacter pylori infection and gastroesophageal reflux disease - Barrett's esophagus sequence \u201cdilemma.\u201d Ann Gastroenterol 2015; 28: 153.","journal-title":"Ann Gastroenterol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00963.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12058"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.109082"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"Kountouras J Doulberis M Polyzos SA et\u00a0al. Helicobacter pylori infection and gastroesophageal reflux disease-Barrett\u2019s esophagus-esophageal adenocarcinoma sequence. Am J Gastroenterol 2018; doi: 10.1038\/s41395-018-0214-5 [Epub ahead of print].","DOI":"10.1038\/s41395-018-0214-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022815902105"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22198-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.06.008"},{"key":"e_1_3_2_21_2","first-page":"392","article-title":"Study on the gastric leptin and Helicobacter pylori associated gastritis","volume":"28","author":"Cui X Lianqing","year":"2005","unstructured":"Cui X Lianqing LI and Hao S. Study on the gastric leptin and Helicobacter pylori associated gastritis. 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