{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:34:14Z","timestamp":1792715654819,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","award":["2015KYB220"],"award-info":[{"award-number":["2015KYB220"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the accuracy of dual-tracer scintigraphy for locating parathyroid adenomas in patients with primary hyperparathyroidism (PHPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed 268 patients with PHPT. All patients underwent technetium-99m pertechnetate (\n                      <jats:sup>99m<\/jats:sup>\n                      TcO\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      ) scintigraphy and technetium-99m methoxyisobutylisonitrile (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI) dual-tracer scintigraphy of the thyroid and parathyroid glands, respectively.\n                      <jats:sup>99m<\/jats:sup>\n                      TcO\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      planar scintigraphy was carried out initially followed by dual-phase\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI single-photon emission computed tomography (SPECT)\/CT the next day. The findings were combined and interpreted. Individual\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI and dual-tracer scintigraphy were both analyzed. The sensitivity, specificity, and accuracy were determined in relation to surgical findings. The average interval between scan and surgery was 13 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The positive and negative predictive values of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI SPECT\/CT were 92.0% and 71.3%, respectively, and the sensitivity, specificity, and accuracy were 88.3%, 79.2%, and 85.8%, respectively. The positive and negative predictive values of dual-tracer scintigraphy were 96.3% and 82.3%, respectively, and the sensitivity, specificity, and accuracy were 92.9%, 90.3%, and 92.2%, respectively. Youden\u2019s index for dual-tracer scintigraphy and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI SPECT\/CT were 0.83 and 0.63, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These finding suggest that\n                      <jats:sup>99m<\/jats:sup>\n                      TcO\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MIBI dual-tracer scintigraphy is more accurate than other scintigraphy methods for detecting parathyroid adenoma, and may thus be the most suitable imaging technique in patients with PHPT.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518813742","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T02:19:43Z","timestamp":1545013183000},"page":"836-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["<sup>99m<\/sup>\n                    TcO\n                    <sub>4<\/sub>\n                    <sup>-<\/sup>\n                    \/\n                    <sup>99m<\/sup>\n                    Tc-MIBI dual-tracer scintigraphy for preoperative localization of parathyroid adenomas"],"prefix":"10.1177","volume":"47","author":[{"given":"Zhongke","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cen","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001447"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318208fed9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000203411.53666.AD"},{"key":"e_1_3_2_5_2","first-page":"241","article-title":"Rapid washout of technetium-99m-MIBI from a large parathyroid adenoma.","volume":"36","author":"B\u00e9nard F","year":"1995","unstructured":"B\u00e9nard F, Lefebvre B, Beuvon F, et\u00a0al. Rapid washout of technetium-99m-MIBI from a large parathyroid adenoma. J Nucl Med 1995; 36: 241\u2013243.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_6_2","first-page":"439","article-title":"Parathyroid adenomas with rapid washout: two case reports","volume":"21","author":"Calendini-Viallet C","year":"1997","unstructured":"Calendini-Viallet C, Rinaldi JP, Bussy E, et\u00a0al. Parathyroid adenomas with rapid washout: two case reports. Med Nucl 1997; 21: 439\u2013443.","journal-title":"Med Nucl"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200112000-00001"},{"key":"e_1_3_2_8_2","first-page":"1801","article-title":"Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium-99m-sestamibi (double-phase study)","volume":"33","author":"Taillefer R","year":"1992","unstructured":"Taillefer R, Boucher Y, Potvin C, et\u00a0al. Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium-99m-sestamibi (double-phase study). J Nucl Med 1992; 33: 1801\u20131807.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199608000-00002"},{"key":"e_1_3_2_10_2","first-page":"37","article-title":"Sestamibi parathyroid scanning and preoperative localization studies for patients with recurrent\/persistent hyperparathyroidism of significant comorbid conditions: development of an optimal localization strategy","volume":"63","author":"Peeler BB","year":"1997","unstructured":"Peeler BB, Martin WH, Sandler MP, et\u00a0al. Sestamibi parathyroid scanning and preoperative localization studies for patients with recurrent\/persistent hyperparathyroidism of significant comorbid conditions: development of an optimal localization strategy. 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