{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:16:11Z","timestamp":1777727771822,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine the role of spherical silica nanoparticles (SiNPs) on human bronchial epithelial (BEAS-2B) cells through inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Human mononuclear (THP-1) cells and BEAS-2B cells were co-cultured in transwell chambers and treated with 800\u2009mmol\/L benzo[\n                      <jats:italic toggle=\"yes\">a<\/jats:italic>\n                      ]pyrene-7, 8-dihydrodiol-9, 10-epoxide (BPDE) and 12.5\u2009\u00b5g\/mL SiNPs for 24 hours. For controls, cells were treated with BPDE alone. Subcutaneous tumorigenicity and epithelial-mesenchymal transition (EMT) of BEAS-2B cells were measured. The cells were blocked with a stromal cell-derived factor-1\u03b1 (SDF-1\u03b1)-specific antibody. EMT was analyzed in cells treated with 800\u2009mmol\/L BPDE and 12.5\u2009\u00b5g\/mL SiNPs relative to matched control cells and xenografts\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      . Serum SDF-1\u03b1 levels were measured in 23 patients with lung adenocarcinoma in Xuanwei, in 25 with lung adenocarcinoma outside Xuanwei, and in 22 with benign pulmonary lesions in Xuanwei.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SiNPs significantly promoted tumorigenesis and EMT, induced the release of SDF-1\u03b1, and activated AKT (ser473) in BEAS-2B cells. EMT and phosphorylated AKT (ser473) and glycogen synthase kinase-3\u03b2 levels were decreased when blocked by SDF-1\u03b1 antibody in BEAS-2B cells. SDF-1\u03b1 was mainly secreted by THP-1 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SiNPs combined with BPDE promote EMT of BEAS-2B cells via the AKT pathway by inducing release of SDF-1\u03b1 from THP-1 cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518814333","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T03:46:02Z","timestamp":1549511162000},"page":"1264-1278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1\u03b1 (SDF-1\u03b1)"],"prefix":"10.1177","volume":"47","author":[{"given":"Chong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"},{"name":"Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Yun","family":"You","sequence":"additional","affiliation":[{"name":"School of Public Health, Kunming Medical University, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Tuo","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4734-5554","authenticated-orcid":false,"given":"Zi-Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"},{"name":"Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0233-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-398"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5414"},{"key":"e_1_3_3_5_2","first-page":"517","article-title":"[Expression of PAH-DNA adducts in lung tissues of Xuanwei female lung cancer patients].","volume":"13","author":"Yang K","year":"2010","unstructured":"Yang K, Huang Y, Zhao G, et\u00a0al. 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