{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:12:27Z","timestamp":1788261147259,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science-technology Support Projects of Huai\u2019an City","award":["HAS2013020"],"award-info":[{"award-number":["HAS2013020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the effect of the leukotriene receptor agonist montelukast combined with methylprednisolone on inflammatory response and peripheral blood lymphocyte subset content in children with mycoplasma pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy-four children were enrolled and randomly divided into a standard treatment group and a montelukast plus methylprednisolone group. Serum levels of inflammatory cytokines and corresponding cytokines of T lymphocyte subsets were measured, and peripheral blood was collected to determine the T cell subset content.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 3 days and 7 days after treatment, serum MCP-1, PCT, ICAM-1, CXCL8, CRP, IFN-\u03b3, and IL-17 levels and peripheral blood Th1 and Th17 content were significantly decreased in both groups, while serum IL-4 and TGF-\u03b2 levels and peripheral blood Treg and Th2 content were significantly increased. However, serum MCP-1, PCT, ICAM-1, CXCL8, CRP, IFN-\u03b3, and IL-17 levels and peripheral blood Th1 and Th17 content were significantly lower while serum IL-4 and TGF-\u03b2 levels and peripheral blood Treg and Th2 content were significantly higher in the montelukast plus methylprednisolone group compared with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia can inhibit inflammatory responses and regulate levels of Th1\/Th2 and Th17\/Treg cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060518820412","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T02:40:51Z","timestamp":1557456051000},"page":"2555-2561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia"],"prefix":"10.1177","volume":"47","author":[{"given":"Hongtu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Huai\u2019an Second People\u2019s Hospital\/The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, Huai\u2019an, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-2487","authenticated-orcid":false,"given":"Xian","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Huai\u2019an Second People\u2019s Hospital\/The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, Huai\u2019an, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liang","sequence":"additional","affiliation":[{"name":"Central Laboratory of Huai\u2019an Second People\u2019s Hospital\/the Affiliated Huai\u2019an Hospital of Xuzhou Medical University, Huai\u2019an, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Children\u2019s Hospital of Suzhou University, Suzhou, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"bibr1-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4394-4"},{"key":"bibr2-0300060518820412","doi-asserted-by":"crossref","first-page":"e0156465","DOI":"10.1371\/journal.pone.0156465","volume":"11","author":"Zhang Y","year":"2016","journal-title":"PloS One"},{"key":"bibr3-0300060518820412","first-page":"548","volume":"31","author":"Gao S","year":"2015","journal-title":"Pak J Med Sci"},{"key":"bibr4-0300060518820412","first-page":"5256","volume":"20","author":"Gong L","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"bibr5-0300060518820412","first-page":"120","volume":"26","author":"Zhou H","year":"2017","journal-title":"China Foreign Medical Treatment"},{"key":"bibr6-0300060518820412","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2818"},{"key":"bibr7-0300060518820412","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00329"},{"key":"bibr8-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.05.002"},{"key":"bibr9-0300060518820412","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2014.46.4.239"},{"key":"bibr10-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0024-4"},{"key":"bibr11-0300060518820412","unstructured":"Wu Hong-tu, Zhou Ting, XUE Liang, et\u00a0al. Curative effect of singulair combined with methylprednisolone in treatment of mycoplasma pneumonia and the effect on inflammatory response and peripheral blood lymphocyte subset content.\n                      J Hainan Med Univ,\n                      2017, 23(11):1467-1470."},{"key":"bibr12-0300060518820412","first-page":"1195","volume":"32","author":"Bu X-F","year":"2016","journal-title":"Chin J Immuno"},{"key":"bibr13-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005452"},{"key":"bibr14-0300060518820412","first-page":"1472","volume":"25","author":"Lin Li WL","year":"2015","journal-title":"Chin J Nosocomiology"},{"key":"bibr15-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230609"},{"key":"bibr16-0300060518820412","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S121928"},{"key":"bibr17-0300060518820412","unstructured":"Xiaohua Han, Liyun Liu, Hong Jing, et\u00a0al. Changes of inflammation-associated factors in children with mycoplasma pneomoniae pneumonia and common system in inflammatory response syndrome.\n                      Chin J Contemp Pediatr\n                      , 2007, 9(4):347-350."},{"key":"bibr18-0300060518820412","doi-asserted-by":"publisher","DOI":"10.5812\/ijp.3807"},{"key":"bibr19-0300060518820412","first-page":"5263","volume":"8","author":"Shao L","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr20-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155648"},{"key":"bibr21-0300060518820412","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23095"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518820412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060518820412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060518820412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:38Z","timestamp":1777459838000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060518820412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1177\/0300060518820412"],"URL":"https:\/\/doi.org\/10.1177\/0300060518820412","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]}}}