{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:19:44Z","timestamp":1777727984574,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"crossref","award":["(SIP 20171099 and 20180060) IPN"],"award-info":[{"award-number":["(SIP 20171099 and 20180060) IPN"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Est\u00edmulos al Desempe\u00f1o en Investigaci\u00f3n, Comisi\u00f3n y Fomento de Actividades Acad\u00e9micas","award":["Instituto Polit\u00e9cnico Nacional"],"award-info":[{"award-number":["Instituto Polit\u00e9cnico Nacional"]}]},{"name":"Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado","award":["Programa E-015 investigaci\u00f3n cient\u00edfica y tecnol"],"award-info":[{"award-number":["Programa E-015 investigaci\u00f3n cient\u00edfica y tecnol"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Up to 28.3% of all biological samples (n\u2009=\u200974) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test, relative risk\u2009=\u200911.38 [95% confidence interval: 5.8\u201322.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519828945","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T01:55:10Z","timestamp":1551405310000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic"],"prefix":"10.1177","volume":"48","author":[{"given":"Brenda","family":"Maldonado-Arriaga","sequence":"first","affiliation":[{"name":"Laboratorio de Metabolismo Experimental e Investigaci\u00f3n Cl\u00ednica; Divisi\u00f3n de Investigaci\u00f3n Cl\u00ednica y Coordinaci\u00f3n de Investigaci\u00f3n, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio de Investigaci\u00f3n Cl\u00ednica y Ambiental, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional Prolongaci\u00f3n de Carpio y Plan de Ayala S\/N Colonia Plutarco El\u00edas Calles, Alcald\u00eda Miguel Hidalgo C.P., Ciudad de M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-476X","authenticated-orcid":false,"given":"No\u00e9","family":"Escobar-Escamilla","sequence":"additional","affiliation":[{"name":"Transferencia de M\u00e9todos Moleculares, Departamento de Biolog\u00eda Molecular y Validaci\u00f3n de T\u00e9cnicas, Instituto de Diagn\u00f3stico y Referencia Epidemiol\u00f3gicos (InDRE), Francisco de P. Miranda # 177, Colonia Unidad Lomas de Plateros, Alcald\u00eda \u00c1lvaro Obreg\u00f3n. Ciudad de M\u00e9xico C.P., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"P\u00e9rez-Razo","sequence":"additional","affiliation":[{"name":"Unidad de An\u00e1lisis y Referencia Virol\u00f3gica, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Lizeth","family":"Alcar\u00e1z-Estrada","sequence":"additional","affiliation":[{"name":"Unidad de An\u00e1lisis y Referencia Virol\u00f3gica, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Flores-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Infertilidad, Biolog\u00eda de la Reproducci\u00f3n C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, F\u00e9lix Cuevas, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moreno-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Infertilidad, Biolog\u00eda de la Reproducci\u00f3n C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, F\u00e9lix Cuevas, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"P\u00e9rez-Cabeza de Vaca","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo Experimental e Investigaci\u00f3n Cl\u00ednica; Divisi\u00f3n de Investigaci\u00f3n Cl\u00ednica y Coordinaci\u00f3n de Investigaci\u00f3n, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Mondrag\u00f3n-Ter\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo Experimental e Investigaci\u00f3n Cl\u00ednica; Divisi\u00f3n de Investigaci\u00f3n Cl\u00ednica y Coordinaci\u00f3n de Investigaci\u00f3n, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Hernandez-Cortez","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Microbiana, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional Prolongaci\u00f3n de Carpio y Plan de Ayala S\/N Colonia Plutarco El\u00edas Calles, Alcald\u00eda Miguel Hidalgo C.P., Ciudad de M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-8247","authenticated-orcid":false,"given":"Graciela","family":"Castro-Escarpulli","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Cl\u00ednica y Ambiental, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional Prolongaci\u00f3n de Carpio y Plan de Ayala S\/N Colonia Plutarco El\u00edas Calles, Alcald\u00eda Miguel Hidalgo C.P., Ciudad de M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-5658","authenticated-orcid":false,"given":"Juan Antonio","family":"Su\u00e1rez-Cuenca","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo Experimental e Investigaci\u00f3n Cl\u00ednica; Divisi\u00f3n de Investigaci\u00f3n Cl\u00ednica y Coordinaci\u00f3n de Investigaci\u00f3n, C.M.N. \u201c20 de Noviembre\u201d, ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcald\u00eda Benito Ju\u00e1rez, C.P., Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"bibr1-0300060519828945","unstructured":"Matorras R.\n                      La infertilidad en Espa\u00f1a, situaci\u00f3n actual y perspectivas\n                      . 5th ed. Madrid, 2011, p.19."},{"key":"bibr2-0300060519828945","unstructured":"Vite J, Ortiz D, Hern\u00e1ndez I. An\u00e1lisis epidemiol\u00f3gico de la Infertilidad en una poblaci\u00f3n mexicana.  M\u00e9xico:  Ginecolog\u00eda Obstetra, 2005, p.360."},{"key":"bibr3-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01104-17"},{"key":"bibr4-0300060519828945","unstructured":"Ausinan V, Moreno G.\n                      Tratado SEIMC de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica\n                      . 1st ed. Madrid, 2006, pp.557\u2013564."},{"key":"bibr5-0300060519828945","first-page":"74","volume":"25","author":"L\u00f3pez-\u00c1vila K","year":"2014","journal-title":"Revista Biom\u00e9dica"},{"key":"bibr6-0300060519828945","first-page":"14","volume":"84","author":"Hern\u00e1ndez-Mar\u00edn I","year":"2016","journal-title":"Ginecol Obstet Mex"},{"key":"bibr7-0300060519828945","volume":"3","author":"Farinati AE.","year":"2009","journal-title":"La Gaceta de Infectolog\u00eda y Microbiolog\u00eda Cl\u00ednica"},{"key":"bibr8-0300060519828945","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.8039"},{"key":"bibr9-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00960-07"},{"key":"bibr10-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.044016-0"},{"key":"bibr11-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1086\/599033"},{"key":"bibr12-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.919220"},{"key":"bibr13-0300060519828945","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.5.18820"},{"key":"bibr14-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.08.008"},{"key":"bibr15-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822011000100032"},{"key":"bibr16-0300060519828945","first-page":"26","volume":"49","author":"Mu\u00f1iz-Becerril B","year":"2010","journal-title":"Noticonaquic"},{"key":"bibr17-0300060519828945","first-page":"225","volume":"41","author":"Foschi C","year":"2018","journal-title":"New Microbiol"},{"key":"bibr18-0300060519828945","first-page":"153","volume":"41","author":"Foschi C","year":"2018","journal-title":"New Microbiol"},{"key":"bibr19-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110943"},{"key":"bibr20-0300060519828945","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.16823"},{"key":"bibr21-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000135992.98883.e4"},{"key":"bibr22-0300060519828945","first-page":"35","volume":"41","author":"Andreeva","year":"2002","journal-title":"Akush Ginekol (Sofiia)"},{"key":"bibr23-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00190.x"},{"key":"bibr24-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052285"},{"key":"bibr25-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-129"},{"key":"bibr26-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2016.07.001"},{"key":"bibr27-0300060519828945","doi-asserted-by":"publisher","DOI":"10.4103\/iju.IJU_407_16"},{"key":"bibr28-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1993.tb01146.x"},{"key":"bibr29-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2005.06.003"},{"key":"bibr30-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183947"},{"key":"bibr31-0300060519828945","first-page":"991","volume":"6","author":"Dhawan B","year":"2012","journal-title":"Indian J Med Res"},{"key":"bibr32-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01439-12"},{"key":"bibr33-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0792-4"},{"key":"bibr34-0300060519828945","unstructured":"NOM-039-SSA2:2002. Para la prevenci\u00f3n y control de las infecciones de transmisi\u00f3n sexual."},{"key":"bibr35-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061481"},{"key":"bibr36-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit752"},{"key":"bibr37-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00070.2014"},{"key":"bibr38-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3854-3856.2002"},{"key":"bibr39-0300060519828945","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1451-1455.2002"},{"key":"bibr40-0300060519828945","first-page":"e22390","volume":"6","author":"Jamalizadeh Bahaabadi S","year":"2014","journal-title":". Nephrourology Mon"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519828945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519828945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519828945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:58Z","timestamp":1777459858000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519828945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/0300060519828945"],"URL":"https:\/\/doi.org\/10.1177\/0300060519828945","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,28]]},"article-number":"0300060519828945"}}