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This review also elaborates on the pathogenesis of levosimendan, including the mechanisms of its anti-inflammatory effects, improvement of myocardial ischaemia, increased synthesis of nitric oxide, vascular endothelial cell protection, increased myocardial contractility, improved diastolic function, and inhibition of hypoxia-inducible factor-1\u03b1 expression. Many clinical studies have proven that levosimendan effectively prevents myocardial dysfunction in sepsis. In addition to the widespread use of levosimendan in patients with heart failure, the role of levosimendan in the treatment of patients with sepsis-induced cardiomyopathy will be increasingly studied and applied in the future.<\/jats:p>","DOI":"10.1177\/0300060519837103","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T08:44:36Z","timestamp":1554713076000},"page":"1817-1828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Levosimendan as a new force in the treatment of sepsis-induced cardiomyopathy: mechanism and clinical application"],"prefix":"10.1177","volume":"47","author":[{"given":"Fei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Chi Feng City Hospital, Inner Mongolia Province, Chifeng, 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