{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:20:04Z","timestamp":1785547204267,"version":"3.56.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,6]]},"abstract":"\n Objective<\/jats:title>\n To evaluate the acceptability, tolerability, and effects on vulvovaginitis symptoms and signs of a non-soap, herbal-based intimate solution (Zelesse\u00ae).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a prospective, observational, multicenter study including adult women with symptoms and signs of vulvovaginitis with various etiologies, including candidiasis, trichomoniasis, bacterial vaginosis, and atrophic and irritative vaginitis. The presence and intensity of signs (edema, erythema, vaginal discharge) and symptoms (pruritus) of vulvovaginitis were evaluated before and after 5\u201315 days of daily use of Zelesse\u00ae alone or as a coadjuvant in antimicrobial therapy. Variables following a normal distribution and categorical variables were analyzed using the Student t-test and chi-square or Fisher\u2019s exact test, respectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total 137 women were enrolled in the study; 87 (63.5%) women received concomitant antimicrobials and 50 (36.5%) used Zelesse\u00ae only. Global symptom scores and frequency of patients with vulvovaginitis signs and symptoms, and their mean intensity, decreased after treatment in both patient groups. Vaginal pH and (in the Zelesse\u00ae-only group) vaginal flora remained unaltered. The product was safe, well tolerated, and highly accepted by patients.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Zelesse\u00ae, the non-soap herbal-based solution in this study, may represent a safe and effective option for symptomatic relief of vulvovaginitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0300060519837820","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T04:16:56Z","timestamp":1557893816000},"page":"2626-2636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Acceptability, tolerability, and effects on symptoms and signs of vulvovaginitis of a non-soap, herbal-based intimate hygiene solution (Zelesse\u00ae)"],"prefix":"10.1177","volume":"47","author":[{"given":"Misericordia","family":"Guinot","sequence":"first","affiliation":[{"name":"Private gynecology office of Dra. Misericordia Guinot Gasull. Pasaje de Llavallol, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Eliseo","family":"Blanco","sequence":"additional","affiliation":[{"name":"Private gynecology clinic of Dres. Blanco y Pacheco. Avenida Juan Carlos I, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Delgado","sequence":"additional","affiliation":[{"name":"Private gynecology office Dr. Juan Luis Delgado. Jara, Cartagena (Murcia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Oliva","sequence":"additional","affiliation":[{"name":"Private gynecology office of Dra. Oliva. San Antonio, Totana (Murcia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Manuel San","family":"Frutos","sequence":"additional","affiliation":[{"name":"Sanchinarro Medical Center. Ana de Austria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibone","family":"Huerta","sequence":"additional","affiliation":[{"name":"Medical Department, ITF Research Pharma S.L.U. San Rafael, Alcobendas (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-9439","authenticated-orcid":false,"given":"Syra","family":"Velasco","sequence":"additional","affiliation":[{"name":"Medical Department, ITF Research Pharma S.L.U. San Rafael, Alcobendas (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Nieto","sequence":"additional","affiliation":[{"name":"Medical Department, ITF Research Pharma S.L.U. San Rafael, Alcobendas (Madrid), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"bibr1-0300060519837820","first-page":"807","volume":"83","author":"Hainer BL","year":"2011","journal-title":"Am Fam Physician"},{"key":"bibr2-0300060519837820","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30316-9"},{"key":"bibr3-0300060519837820","first-page":"1095","volume":"62","author":"Egan ME","year":"2000","journal-title":"Am Fam Physician"},{"key":"bibr4-0300060519837820","first-page":"335","volume":"25","author":"Sobel JD.","year":"1999","journal-title":"Compr Health"},{"key":"bibr5-0300060519837820","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.871696"},{"key":"bibr6-0300060519837820","first-page":"2125","volume":"70","author":"Owen MK","year":"2004","journal-title":"Am Fam Physician"},{"key":"bibr7-0300060519837820","first-page":"353","volume":"60","author":"Guaschino S","year":"2008","journal-title":"Minerva Ginecol"},{"key":"bibr8-0300060519837820","first-page":"105","volume":"60","author":"Guaschino S","year":"2008","journal-title":"Minerva Ginecol"},{"key":"bibr9-0300060519837820","first-page":"s13","volume":"7","author":"Wu J.","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"bibr10-0300060519837820","first-page":"85","volume":"144","author":"Feily A","year":"2009","journal-title":"G Ital Dermatol Venereol"},{"key":"bibr11-0300060519837820","first-page":"S72","volume":"9","author":"Fowler JF","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"bibr12-0300060519837820","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-010-0062-4"},{"key":"bibr13-0300060519837820","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-9-4"},{"key":"bibr14-0300060519837820","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2013.12.002"},{"key":"bibr15-0300060519837820","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.162118"},{"key":"bibr16-0300060519837820","doi-asserted-by":"publisher","DOI":"10.1080\/20786204.2005.10873183"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519837820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519837820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519837820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:09Z","timestamp":1777459869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519837820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1177\/0300060519837820"],"URL":"https:\/\/doi.org\/10.1177\/0300060519837820","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]}}}