{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:22:21Z","timestamp":1777728141941,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      commonly occurs in the stomach, but localizations outside the stomach and related diseases have also been investigated. However, the relationship between\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      and gallstones remains controversial. We aimed to investigate the relationships between\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in the stomach and the gallbladder and gallstones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective case-control study included patients who underwent cholecystectomy because of gallstones, pancreatic head cancer, or hepatic resection. The patients were separated into two groups according to the detection of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in gallbladder samples using Giemsa staining. Stomach\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      status was based on previous gastroscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enrolled 60 patients, comprising 27 patients with gallstones and 33 without. There was no significant difference in the incidence of gallstones between patients with or without\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in the stomach or gallbladder. Furthermore, the presence of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in the stomach was measured in 14 patients and was significantly correlated with\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in the gallbladder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The current study showed no relationship between the occurrence of gallstones and the presence of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in either the gallbladder or the stomach. In contrast to previous reports, this suggests that\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      does not play a role in the development of gallstones.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519847345","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T04:18:52Z","timestamp":1566447532000},"page":"4904-4910","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between\n                    <i>Helicobacter pylori<\/i>\n                    -positivity in the gallbladder and stomach and effect on gallbladder pathologies"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-2354","authenticated-orcid":false,"given":"Aziz","family":"Ari","sequence":"first","affiliation":[{"name":"Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-9655","authenticated-orcid":false,"given":"Cihad","family":"Tatar","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Yarikkaya","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital, Department of Pathology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.172"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.031"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01282.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.026"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_3_3_8_2","first-page":"177","article-title":"Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic over-view","volume":"150","author":"Veldhuyzen van Zanten SJ","year":"1994","unstructured":"Veldhuyzen van Zanten SJ, Sherman PM. Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic over-view. Can Med Assoc J 1994; 150: 177\u2013185.","journal-title":"Can Med Assoc J"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.12781"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389534"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502010000300002"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410009546"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-013-0321-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070265"},{"key":"e_1_3_3_16_2","article-title":"Helicobacter pylori in cholecystectomy specimens-morphological and immunohistochemical assessment","volume":"10","author":"Patnayak R","year":"2016","unstructured":"Patnayak R, Reddy V, Jena A, et\u00a0al. Helicobacter pylori in cholecystectomy specimens-morphological and immunohistochemical assessment. Clin Diagn Res 2016; 10: EC01-3. doi: 10.7860\/JCDR\/2016\/14802.7716.","journal-title":"Clin Diagn Res"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.15171\/mejdd.2017.86"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12457"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027390"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3444-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10893"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12332"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-2-11"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70066-5"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i14.2181"},{"key":"e_1_3_3_26_2","first-page":"1207","article-title":"Association between Helicobacter pylori infection and gallbladder diseases: a retrospective study.","volume":"27","author":"Xu MY","year":"2017","unstructured":"Xu MY, Ma JH, Yuan BS, et\u00a0al. Association between Helicobacter pylori infection and gallbladder diseases: a retrospective study. 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