{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:28:25Z","timestamp":1780421305562,"version":"3.54.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Objective<\/jats:title>\n \n We aimed to describe the clinical characteristics and treatment outcomes of 16 patients with\n Brucella<\/jats:italic>\n -induced thrombocytopenia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We assessed 16 patients with\n Brucella<\/jats:italic>\n -induced thrombocytopenia between 2012 and 2016 in The First Affiliated Hospital of Xinjiang Medical University. The diagnosis of\n Brucella<\/jats:italic>\n -induced thrombocytopenia was \u2264100,000 platelets\/mm\n 3<\/jats:sup>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All patients were men. The most common symptoms of patients were fever (100%), sweating (81.2%), fatigue (75%), and joint pain (25%). The most common signs of physical examinations were an enlarged liver (75%) and enlarged spleen (50%). The lowest thrombocyte count was 2000\/mm\u00b3 and the highest count was 72,000\/mm\u00b3. An agglutination test antibody was positive (\u22651:160) in 12 (75%) patients with the highest antibody titer of 1:800.\n Brucella melitensis<\/jats:italic>\n was isolated from blood cultures in nine (56.3%) patients. All patients were administered antimicrobial agents. The patients\u2019 platelet counts were normal at a follow-up of 12 months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Classical brucellosis therapy is adequate for patients with a platelet count >\u200920,000\/mm\n 3<\/jats:sup>\n . The five-drug regimen of doxycycline\u2009+\u2009rifampin\u2009+\u2009platelet transfusions\u2009+ \u2009corticosteroids\u2009+\u2009intravenous immunoglobulin is recommended for patients when the platelet count is\u2009<\u200910,000\/mm\n 3<\/jats:sup>\n . These findings have important implications for improving treatment outcome in patients with\n Brucella<\/jats:italic>\n -induced thrombocytopenia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0300060519847406","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T03:03:45Z","timestamp":1559531025000},"page":"3008-3013","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Brucella<\/i>\n -induced thrombocytopenia: a retrospective study of 16 patients"],"prefix":"10.1177","volume":"47","author":[{"given":"Songsong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"},{"name":"The First Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjiong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weize","family":"Zuo","sequence":"additional","affiliation":[{"name":"The First Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70286-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/318129"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.12980\/APJTB.4.2014C1324"},{"key":"e_1_3_3_6_2","first-page":"218","article-title":"Recurrent epistaxis and bleeding as the initial manifestation of brucellosis.","volume":"54","author":"Kamali AM","year":"2016","unstructured":"Kamali AM, Davari K, Eftekhari K. Recurrent epistaxis and bleeding as the initial manifestation of brucellosis. Acta Med Iran 2016; 54: 218\u2013219.","journal-title":"Acta Med Iran"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.12980\/apjtd.7.2017D6-406"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0834"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.151710"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005577"},{"key":"e_1_3_3_11_2","first-page":"303","article-title":"Severe thrombocytopenia and hemorrhagic diathesis due to brucellosis.","volume":"15","author":"Karsen H","year":"2012","unstructured":"Karsen H, Duygu F, Yap\u0131c\u0131 K, et\u00a0al. Severe thrombocytopenia and hemorrhagic diathesis due to brucellosis. Arch Iran Med 2012; 15: 303\u2013306.","journal-title":"Arch Iran Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001865"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519847406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519847406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519847406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:24Z","timestamp":1777459884000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519847406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,3]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/0300060519847406"],"URL":"https:\/\/doi.org\/10.1177\/0300060519847406","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,3]]}}}