{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:30:00Z","timestamp":1785004200412,"version":"3.55.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the role of long non-coding (lnc) RNA-NEF (neighboring enhancer of FoxA2), a characterized oncogene in cancer biology, in postmenopausal osteoporosis and its diagnostic and prognostic value in this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Expression of lncRNA-NEF in plasma was detected by RNA extraction and real-time quantitative PCR. The diagnostic value of lncRNA-NEF and interleukin (IL)-6 for postmenopausal osteoporosis was evaluated by receiver operating characteristic curve analysis, with postmenopausal osteoporosis patients as true positive cases and healthy volunteers as true negative cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We showed that plasma lncRNA-NEF was downregulated and plasma IL-6 was upregulated in postmenopausal osteoporosis patients compared with healthy controls. Altered plasma levels of lncRNA-NEF and IL-6 separated postmenopausal osteoporosis patients from healthy controls, and lncRNA-NEF and IL-6 were inversely and significantly correlated in osteoporosis patients. Patients were divided into high (n\u2009=\u200968) and low lncRNA-NEF (n\u2009=\u200973) groups according to Youden\u2019s index. Patients with high lncRNA-NEF levels required a significantly shorter treatment course and had a lower post-treatment recurrence rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We showed that lncRNA-NEF is downregulated in postmenopausal osteoporosis and is related to course of treatment and recurrence. The involvement of lncRNA-NEF in postmenopausal osteoporosis is likely related to IL-6.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519847854","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T02:21:54Z","timestamp":1561083714000},"page":"3299-3306","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["LncRNA-NEF is downregulated in postmenopausal osteoporosis and is related to course of treatment and recurrence"],"prefix":"10.1177","volume":"47","author":[{"given":"Xiaoyong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixue","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, The Second Hospital of Baoding, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Lixian Hospital, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-1581","authenticated-orcid":false,"given":"Wenkui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Hebei University, Baoding City, Hebei Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-070313-022841"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.69"},{"key":"e_1_3_4_4_2","first-page":"492","article-title":"Incidence rate of potential osteonecrosis of the jaw among women with postmenopausal osteoporosis treated with Prolia or bisphosphonates: abstract number 348.","volume":"67","author":"Xue F","year":"2015","unstructured":"Xue F, Wagman RB, Yue S, et\u00a0al. Incidence rate of potential osteonecrosis of the jaw among women with postmenopausal osteoporosis treated with Prolia or bisphosphonates: abstract number 348. Arthritis Rheum, 2015; 67: 492\u2013495.","journal-title":"Arthritis Rheum"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3502-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12369"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003039"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl046"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.06.013"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.04.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2014.998617"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0041-y"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110802"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(96)01080-8"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5180"},{"key":"e_1_3_4_17_2","first-page":"3537","article-title":"Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis","volume":"41","author":"Fei Q","year":"2018","unstructured":"Fei Q, Bai X, Lin J, et\u00a0al. Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis. 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