{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:09:05Z","timestamp":1781582945753,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Social Development Program of Science Technology Department of Zhejiang Province, China","award":["2013C33099"],"award-info":[{"award-number":["2013C33099"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the distribution of subtypes between HLA-B*27 (+) patients with ankylosing spondylitis (AS) and carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study recruited Chinese Han patients with HLA-B*27 (+) AS from six hospitals in Zhejiang Province, China between 2013 and 2018. Patients who were examined for HLA-B*27 because of back pain or arthralgia but who did not have AS or arthritis were recruited as controls. HLA-B*27 target DNA was amplified by amplification refractory mutation systems and HLA-B*27 subtypes were determined by sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The positive rate of HLA-B*27 was significantly higher in the AS group than in the control group. In AS patients, HLA-B*2704 was predominant at 86.4%, followed by HLA-B*2705 at 12.6%; HLA-B*2704 and HLA-B*2705 were found in 70.0% and 10.0% of controls, respectively. HLA-B*2702 and HLA-B*2706 were detected at low frequencies in the control group, while the rare subtype HLA-B*2715 was only observed in two (1.0%) patients with AS. HLA-B*2707 was not detected in AS or control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HLA-B*2704 is the predominant subtype among patients with AS and carriers in southeast China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519853929","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T05:01:43Z","timestamp":1560142903000},"page":"3171-3178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of HLA-B*27 subtypes between Chinese patients with ankylosing spondylitis and non-ankylosing spondylitis carriers"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-7773","authenticated-orcid":false,"given":"Fangjun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Zhuji Hospital of Wenzhou Medical University, Zhuji, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai ZJ Bio-Tech Co., Ltd, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhang","family":"Leng","sequence":"additional","affiliation":[{"name":"Central Laboratory of Hangzhou First People\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.01.003"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(02)00360-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.883"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1115-8_5"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0298-6_12"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(98)01375-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2007.01450.x"},{"key":"e_1_3_4_11_2","first-page":"1189","article-title":"HLA-B27 subtypes in Japanese with seronegative spondyloarthropathies and healthy controls.","volume":"23","author":"Yamaguchi A","year":"1996","unstructured":"Yamaguchi A, Ogawa A, Tsuchiya N, et\u00a0al. 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