{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:24:39Z","timestamp":1777728279003,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effectiveness of pre-treatment with aripiprazole and quetiapine to prevent acute cocaine toxicity in a mouse model of cocaine toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This experimental study included three groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200925 per group) of mice that were intraperitoneally injected with normal saline solution, 10 mg\/kg quetiapine or 10 mg\/kg aripiprazole 15 min before 105 mg\/kg cocaine hydrochloride. When the cocaine administration was completed, researchers blinded to the study groups observed the mice in terms of seizures and death for a further 30 min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cocaine\u2009+\u2009quetiapine group, the mean\u2009\u00b1\u2009SE time to the first seizure was 10.80\u2009\u00b1\u20092.27 min and seizure activity was detected in 18 mice (72%) by the end of the 30 min. In the cocaine\u2009+\u2009aripiprazole group, the mean\u2009\u00b1\u2009SE time to the first seizure was 18.10\u2009\u00b1\u20091.94 min and seizure activity was detected in 15 mice (60%) by the end of the 30 min. When compared with the control group, there was a significant difference between the cocaine\u2009+\u2009quetiapine and cocaine\u2009+\u2009aripiprazole groups in terms of seizure activity. Survival time was increased in the cocaine\u2009+\u2009aripiprazole group compared with the control and cocaine\u2009+\u2009quetiapine groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quetiapine and aripiprazole pre-treatment reduced seizure activity and delayed the onset of seizures compared with the control group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519854631","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T05:44:39Z","timestamp":1560318279000},"page":"3831-3840","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-5681","authenticated-orcid":false,"given":"Atakan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Erdur","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mert","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Sabirli","sequence":"additional","affiliation":[{"name":"Emergency Service, Servergazi State Hospital, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Turkcuer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Sarohan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, University of Kyrenia, Kyrenia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Seyit","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Crane EH. 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