{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:33:07Z","timestamp":1792629187031,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the risk of acute and late toxicities of concurrent chemoradiotherapy (CCRT) and radiotherapy alone in patients with nasopharynx carcinoma (NPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this meta-analysis, we searched the PubMed, Embase, Cochrane Library, and Web of Science databases for eligible randomized clinical trials (RCTs). In addition to the incidence of specific toxicities, risk ratios (RRs) or odd ratios (ORs) and 95% confidence intervals (CIs) were obtained using fixed-effect or random-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 11 RCTs involving 2801 patients with NPC were included in this analysis. For grade \u22653 adverse events, patients who received CCRT treatment had a higher proportion of acute mucositis (39.9% vs. 30.5%, RR=1.30, 95%CI, 1.16\u20131.46) acute nausea and vomiting (RR=6.26, 95% CI: 2.01\u201319.45), and neutropenia (RR=30.86, 95% CI: 7.36 to 129.35). For late severe toxicities, CCRT treatment was significantly associated with higher incidence of hearing loss (116.56% vs. 411.43%, RR=1.461, 95%CI, 1.043\u201321.095). The incidence of acute nausea and vomiting was more frequent in patients receiving CCRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with radiotherapy alone, CCRT increases the risk of severe acute toxicities (mucositis, nausea\/vomiting, and neutropenia) and severe late toxicity (hearing loss) in patients with NPC. However, larger studies are needed to confirm this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519858031","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T04:33:10Z","timestamp":1562301190000},"page":"2832-2847","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Toxicities of chemoradiotherapy and radiotherapy in nasopharyngeal carcinoma: an updated meta-analysis"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-9501","authenticated-orcid":false,"given":"Chun","family":"Wang","sequence":"first","affiliation":[{"name":"Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Min","sequence":"additional","affiliation":[{"name":"Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-juan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine &amp; Health Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.009.10329"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.018"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-558"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.9347"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.084"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1310"},{"key":"e_1_3_7_8_2","first-page":"218","article-title":"[Concurrent chemoradiotherapy versus radiotherapy alone for locoregionally advanced nasopharyngeal carcinoma: a meta-analysis].","volume":"43","author":"Yang AK","year":"2008","unstructured":"Yang AK, Liu TR, Guo X, et\u00a0al. 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