{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:26:44Z","timestamp":1777728404301,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute decompensation (AD) in liver cirrhosis has high mortality. We assessed prognostic scoring models and established prediction models for different etiologies of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included 732 patients hospitalized with acute decompensated cirrhosis without acute-on-chronic liver failure. We performed logistic regression analysis of risk factors for mortality associated with different etiologies, to establish predictive models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with different etiologies, scored using different scoring systems and various impact factors, exhibited differences with respect to mortality. MELD, CLIF-C-AD, MELD-Na, and AARC-ACLF scores exhibited adequate predictive ability for mortality. Area under the receiver operating characteristic curve for 28-day mortality for MELD, CLIF-C-AD, MELD-Na, AARC-ACLF, and the newly developed AD scores was 0.663, 0.673, 0.657, 0.662, and 0.773, respectively, in the hepatitis B virus group (HBV-AD score =\u22125.51\u2009+\u20090.07*WBC count (10\n                      <jats:sup>9<\/jats:sup>\n                      \/L) +0.7*AD sum+0.4*AARC-ACLF score); 0.731, 0.737, 0.735, 0.689, and 0.778, respectively, in the alcoholic liver disease group (ALD-AD score =\u22124.55 +0.08* WBC count (10\n                      <jats:sup>9<\/jats:sup>\n                      \/L) +1.34* AD sum); and 0.765, 0.767, 0.814, 0.720, and 0.814, respectively, in the Others group (OTHERS-AD score =\u22122.14\u2009+\u20091.24*MELD-Na score +4.49*AD sum).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The newly developed scoring models for short-term mortality were superior to the other scoring systems in predicting prognosis of acute decompensated cirrhosis in hospitalized patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519862065","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T05:41:45Z","timestamp":1564551705000},"page":"4492-4504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of prognostic scoring models for different etiologies of acute decompensation in hospitalized patients with cirrhosis"],"prefix":"10.1177","volume":"47","author":[{"given":"Qun","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Affiliated Chaohu Hospital of Anhui Medical University, Chaohu, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinnan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifang","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"bibr1-0300060519862065","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"bibr2-0300060519862065","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12480"},{"key":"bibr3-0300060519862065","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27849"},{"key":"bibr4-0300060519862065","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.012"},{"key":"bibr5-0300060519862065","first-page":"OC12","volume":"11","author":"El-Ghannam MT","year":"2017","journal-title":"J Clin 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