{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:53:49Z","timestamp":1792799629027,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"This Science and Technology Department of Jiangxi Province, China","award":["S2017YBYFE1007."],"award-info":[{"award-number":["S2017YBYFE1007."]}],"id":[{"id":"https:\/\/ror.org\/040ebrp24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the potential for pulpal regeneration via autologous transplantation of deciduous tooth pulp into immature necrotic permanent teeth using an experimental dog model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experimental apical periodontitis was induced in 60 teeth of six Beagle dogs. Following canal disinfection and pulpotomy, autologous deciduous pulp tissue was transplanted into the root canals (n\u2009=\u200930); as controls, contralateral teeth were treated in accordance with the recommendations of the American Association of Endodontists. Radiographic examinations were performed immediately before transplant, as well as 3 and 6 months after transplant. At the 6-month examination, root samples were collected and histological and immunohistochemical analyses were used to examine tissue regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Radiographic analysis showed no significant differences in most histopathological parameters examined; however, apical diameter reduction was greater in the experimental group. Histological and immunohistochemical analyses showed that the canal walls of the experimental group had newly formed dentin-like tissue with dentinal tubules, while the control group had cementum-like deposits along the canal wall and apical foramina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Autologous transplantation may be useful for regeneration of dental pulp in necrotic young permanent teeth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519862094","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T05:41:38Z","timestamp":1564551698000},"page":"5094-5105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Autologous transplantation of deciduous tooth pulp into necrotic young permanent teeth for pulp regeneration in a dog model"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-2619","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"first","affiliation":[{"name":"Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Department of Pediatric Dentistry, Jiangxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[{"name":"Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Department of Pediatric Dentistry, Jiangxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer C.","family":"Cehreli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Dai","sequence":"additional","affiliation":[{"name":"Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Department of Pediatric Dentistry, Jiangxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjingjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Department of Pediatric Dentistry, Jiangxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Department of Pediatric Dentistry, Jiangxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"47","article-title":"Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature","volume":"29","author":"Thibodeau B","year":"2007","unstructured":"Thibodeau B, Trope M. 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