{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:12:13Z","timestamp":1777727533305,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the establishment of a new linkage model between tertiary hospitals and community hospitals for a study of prevention and cure of childhood asthma","award":["10DZ1951000"],"award-info":[{"award-number":["10DZ1951000"]}]},{"name":"the risk factors of recurrent infant wheeze and early intervention study in Pujiang town","award":["SHDC12014905"],"award-info":[{"award-number":["SHDC12014905"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess whether orosomucoid 1-like 3 (ORMDL3) expression and environmental and clinical factors are associated with wheezing episodes in preschool children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children diagnosed with wheezing episodes were classified according to their asthma predictive index (API) in the past year as follows: API+ (\u22654 wheezing episodes), API\u2212 (1\u20133 wheezing episodes), and API0 (without wheezing). ORMDL3 expression was assessed by real-time polymerase chain reaction in peripheral blood mononuclear cells (PBMCs). Receiver operating characteristic curve analysis of\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression and the API was performed for diagnosing wheezing episodes. Correlations between\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression and asthma risk factors were examined using Spearman\u2019s correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PBMC\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression was higher in the API+ group compared with the API\u2212 and API0 groups. The area under the curve for\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression was 0.820 (95% confidence interval, 0.771\u20130.869).\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression was positively correlated with the API (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.447), infantile eczema (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.499), wheezing (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.516), total immunoglobulin E (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.208), and environmental factors, including\n                      <jats:italic toggle=\"yes\">Dermatophagoides pteronyssinus<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.357), house dust mites (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.112), dog fur (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.226), and\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.257).\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression was negatively correlated with amaranth (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u22120.122).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">ORMDL3<\/jats:italic>\n                      expression in PBMCs is positively associated with the API and some asthma-related clinical and environmental risk factors in preschoolers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519862674","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T05:19:52Z","timestamp":1564031992000},"page":"3727-3736","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between peripheral blood mononuclear cell\n                    <i>ORMDL3<\/i>\n                    expression and the asthma predictive index in preschool children"],"prefix":"10.1177","volume":"47","author":[{"given":"Yaqin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-2574","authenticated-orcid":false,"given":"Yanming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, South Campus, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.032"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6705e1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-011-0206-7"},{"key":"e_1_3_3_6_2","unstructured":"Global Initiative for Asthma (GINA). 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