{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:21Z","timestamp":1787018781463,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Myasthenia gravis (MG) and premature ovarian failure (POF) are rare. MF and POF greatly affect patients\u2019 health. Combined occurrence of MF and POF in young women can have serious consequences. We report two cases of MG with POF. Case 1 was a 20-year-old woman who presented with myasthenic crisis and menopause in September 2015 and November 2015, respectively. The patient\u2019s estradiol and follicle-stimulating hormone levels were abnormal. She was administered plasmapheresis and methylprednisolone pulse therapy. She improved and was discharged with normal restoration of menstruation after 3 months. Case 2 was a 21-year-old woman who had right eyelid droop and double vision in June 2014. She presented with menstrual disorder and menopause in August 2014 and September 2014, respectively. Estradiol and follicle-stimulating hormone levels were abnormal. She underwent progesterone therapy. She was admitted to hospital again in March 2016 with a myasthenic crisis. She received methylprednisolone pulse therapy and underwent thymectomy, but menstruation was not restored. In conclusion, there is comorbidity of POF in MG, and there is a close relationship between these two diseases. MG may subsequently lead to development of POF, and timely immunotherapy for MG may normalize POF.<\/jats:p>","DOI":"10.1177\/0300060519863525","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T05:18:36Z","timestamp":1564031916000},"page":"3992-3997","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical characteristics and relationship between myasthenia gravis and premature ovarian failure: report of two cases"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-9347","authenticated-orcid":false,"given":"Liming","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Shenzhen University, Shenzhen City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Shenzhen University, Shenzhen City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590009167696"},{"key":"e_1_3_5_4_2","first-page":"368","article-title":"Chinese experts' consensus on diagnosis and treatment of myasthenia gravis","volume":"18","author":"Neuroimmunology Society of the Chinese Society of Immunology, Neurological Immunology Group of the Society of Neurology of the Chinese Medical Association","year":"2011","unstructured":"Neuroimmunology Society of the Chinese Society of Immunology, Neurological Immunology Group of the Society of Neurology of the Chinese Medical Association. Chinese experts' consensus on diagnosis and treatment of myasthenia gravis. Chin J Neuroimmunol Neurol 2011; 18: 368\u2013372.","journal-title":"Chin J Neuroimmunol Neurol"},{"key":"e_1_3_5_5_2","first-page":"826","article-title":"A case of myasthenia gravis complicated with premature ovarian failure","volume":"39","author":"Li Y","year":"2006","unstructured":"Li Y, Yang H, Xiao B, et\u00a0al. A case of myasthenia gravis complicated with premature ovarian failure. Chinese J Neurol 2006; 39: 826.","journal-title":"Chinese J Neurol"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1995.tb00899.x"},{"key":"e_1_3_5_7_2","first-page":"117","article-title":"Myasthenia gravis complicated with premature ovarian failure 1 cases report","volume":"24","author":"Dong JD","year":"2011","unstructured":"Dong JD, Wang XS, Jin L. Myasthenia gravis complicated with premature ovarian failure 1 cases report. J Clinical Neurol 2011; 24: 117.","journal-title":"J Clinical Neurol"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20067"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5050"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2737"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1993.tb00382.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519863525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519863525","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519863525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:43Z","timestamp":1777459783000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519863525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/0300060519863525"],"URL":"https:\/\/doi.org\/10.1177\/0300060519863525","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}