{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:27:12Z","timestamp":1779251232003,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"\n Objective<\/jats:title>\n To ascertain plasma levels of heat shock protein 90\u03b1 (HSP90\u03b1) and squamous cell carcinoma antigen (SCC-Ag) and their diagnostic potential in cervical cancer.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a cross-sectional study, patients\u2019 cervical tissue samples were screened for high risk (HR) human papilloma virus (HPV) DNA and underwent a thinprep-liquid based cytology test (TCT). Plasma samples were analysed by enzyme-linked immunosorbent assay (ELISA) for HSP90 \u03b1 and SCC-Ag levels.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 295 women who underwent screening, 75 were healthy controls 75 (HR-HPV\n \u2212ve<\/jats:sup>\n TCT\n \u2212ve<\/jats:sup>\n ), 110 were HR-HPV\n +ve<\/jats:sup>\n , TCT\n \u2212ve<\/jats:sup>\n and 110 were HR-HPV\n +ve<\/jats:sup>\n TCT\n +ve<\/jats:sup>\n . There were significant differences between levels of HSP90\u03b1 and SCC-Ag proteins across the patient groups with those positive for cervical cancer having the greatest levels of proteins compared with other groups. For patients with high grade SCC there was a significant correlation between levels of HSP90\u03b1 and SCC-Ag. The area under the ROC curve for combined HSP90\u03b1*SCC-Ag was the largest compared with the single proteins. Using a cut-off value of 16.4 ng\/ml to delineate cervical cancer diagnosis, the sensitivity and specificity of HSP90\u03b1*SCC-Ag were 90.3% and 95.1% respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Plasma HSP90\u03b1 protein levels correlated well with SCC-Ag levels in patients with cervical cancer and the combination of HSP90\u03b1*SCC-Ag may be a useful diagnostic biomarker.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0300060519865634","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T04:34:56Z","timestamp":1566275696000},"page":"5518-5525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic value of heat shock protein 90\n \u03b1<\/b>\n and squamous cell carcinoma antigen in detection of cervical cancer"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-7571","authenticated-orcid":false,"given":"Songtao","family":"Han","sequence":"first","affiliation":[{"name":"Clinical Laboratory Center, the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi, Xinjiang Uygur Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi, Xinjiang Uygur Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi, Xinjiang Uygur Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi, Xinjiang Uygur Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"bibr1-0300060519865634","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S195349"},{"key":"bibr2-0300060519865634","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.079"},{"key":"bibr3-0300060519865634","first-page":"119","volume":"36","author":"Hu SY","year":"2014","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"bibr4-0300060519865634","unstructured":"World Health Organization. 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