{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:21:33Z","timestamp":1783570893569,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Vitiligo is a common pigmentation disorder of the skin, and its pathogenesis remains unclear. We evaluated the effectiveness of compound glycyrrhizin combined with fractional carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) laser and triamcinolone acetonide solution in patients with vitiligo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with stable vitiligo treated at our hospital between May 2016 and August 2017 were randomized to a control group or an observation group. Both groups were treated with fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser and triamcinolone acetonide solution, while the observation group also received compound glycyrrhizin. Clinical effectiveness, serum IL-17 and TGF-\u03b2 levels, and adverse drug reactions were compared between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following treatment, the clinical effective rate was significantly higher in the observation group than in the control group (75.00% vs. 52.50%). Furthermore, IL-17 decreased in both groups but was significantly lower in the observation group, while TGF-\u03b2 increased in both groups but was significantly higher in the observation group. The incidence of adverse drug reactions was not significantly different between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Compound glycyrrhizin in combination with fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser and triamcinolone acetonide solution can be used to treat vitiligo and appears to modulate cytokine levels. Trial registration: Hebei Provincial Administration of Traditional Chinese Medicine (no. 2019366; http:\/\/www.hebwst.gov.cn\/index.do?templet=cs_zyj )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519871382","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T04:54:28Z","timestamp":1569387268000},"page":"5623-5631","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of vitiligo treatment using compound glycyrrhizin combined with fractional carbon dioxide laser and topical triamcinolone acetonide on serum interleukin-17 and tissue growth factor-\n                    <b>\n                      <i>\u03b2<\/i>\n                    <\/b>\n                    levels"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-8104","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Baoding First Central Hospital, Baoding, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Baoding First Central Hospital, Baoding, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Baoding First Central Hospital, Baoding, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"bibr1-0300060519871382","unstructured":"Bian Z. Chinese clinical dermatology.  Phoenix Science Press, 2010, pp.1270\u20131271."},{"key":"bibr2-0300060519871382","doi-asserted-by":"publisher","DOI":"10.3109\/08916930108994127"},{"key":"bibr3-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"bibr4-0300060519871382","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2013.12053"},{"key":"bibr5-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"bibr6-0300060519871382","first-page":"373","volume":"43","year":"2010","journal-title":"Chinese J of Dermatology"},{"key":"bibr7-0300060519871382","first-page":"5","volume":"16","author":"Taieb A.","year":"2012","journal-title":"Br J Dermatol"},{"key":"bibr8-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2455::AID-ANR12>3.0.CO;2-K"},{"key":"bibr9-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311430693"},{"key":"bibr10-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00945.x"},{"key":"bibr11-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00045.x"},{"key":"bibr12-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"bibr13-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701242RR"},{"key":"bibr14-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.01.004"},{"key":"bibr15-0300060519871382","first-page":"2565","volume":"16","author":"Krasagakis K","year":"1994","journal-title":"Anticancer Res"},{"key":"bibr16-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282ef869e"},{"key":"bibr17-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1254605"},{"key":"bibr18-0300060519871382","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.048"},{"key":"bibr19-0300060519871382","first-page":"1061","volume":"14","author":"Wohlrab J.","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"bibr20-0300060519871382","unstructured":"Suntiparpluacha M, Tammachote N, Tammachote R. Triamcinolone acetonide reduces viability, induces oxidative stress, and alters gene expressions of human chondrocytes. [J]. 2016;  20: 4985\u20134992"},{"key":"bibr21-0300060519871382","doi-asserted-by":"crossref","unstructured":"Makboul M, Makboul R, Abdelhafez AH, et\u00a0al.  Evaluation of the effect of fractional CO2 laser on histopathological picture and TGF-\u03b21 expression in hypertrophic scar. [J]. 2014;  13: 169\u2013179.","DOI":"10.1111\/jocd.12099"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519871382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519871382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519871382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:04Z","timestamp":1777459804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519871382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/0300060519871382"],"URL":"https:\/\/doi.org\/10.1177\/0300060519871382","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]}}}