{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:43Z","timestamp":1777727743373,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Applied Technology and Development Project of the Harbin Science and Technology Agency","award":["2014RFQGJ010"],"award-info":[{"award-number":["2014RFQGJ010"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate clinical characteristics of early-onset invasive pulmonary aspergillosis (IPA) in nonneutropenic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis was used to investigate clinical manifestations and auxiliary examination characteristics in 43 patients with IPA and 51 patients with community-acquired pneumonia in the early stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Risk factors of IPA were dust and mold exposure, bronchiectasis, old pulmonary tuberculosis, and nasosinusitis. The incidence rate of complex clinical manifestations was 60.47% during the first week of IPA. The incidence rate of white blood cell (WBC) count &gt;20.0\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L was 51.16%. Lung CT findings indicated incidence rates of single or multiple nodules with a halo sign and central airway expansion with ground glass opacity were 27.9% and 37.21%, respectively. Mortality rates of patients with IPA given empirical and targeted antifungal treatments were 12.0% and 42.9%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Bronchiectasis, old pulmonary tuberculosis, nasosinusitis, and dust and mold exposure may increase the risk of IPA. Single or multiple nodules with a halo sign and central airway expansion with ground glass opacity may be early-stage lung CT findings in patients with IPA. A WBC count &gt;20.0\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L may aid in early diagnosis, and empirical antifungal therapy may reduce mortality in patients with IPA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519874901","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T23:05:56Z","timestamp":1569884756000},"page":"5680-5688","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical manifestations and outcome analysis of invasive pulmonary aspergillosis infection: a retrospective study in 43 nonneutropenic patients"],"prefix":"10.1177","volume":"47","author":[{"given":"Lihong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-3402","authenticated-orcid":false,"given":"Chunli","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"bibr1-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03697.x"},{"key":"bibr2-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2011.09.017"},{"key":"bibr3-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"bibr4-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"bibr5-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"bibr6-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00212-0"},{"key":"bibr7-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1636"},{"key":"bibr8-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/509917"},{"key":"bibr9-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.03.005"},{"key":"bibr10-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/657065"},{"key":"bibr11-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00673-10"},{"key":"bibr12-0300060519874901","unstructured":"Kyo K, Ochi T, Okatani T, et\u00a0al. Is halo sign the earliest sign of pulmonary invasive aspergillosis (IPA).\n                      Program and Abstracts of the 52th Interscience Conference on Antimicrobial Agents and Chemotherapy\n                      2012; AM-1226."},{"key":"bibr13-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/595846"},{"key":"bibr14-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1086\/600380"},{"key":"bibr15-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir441"},{"key":"bibr16-0300060519874901","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03685.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519874901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519874901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519874901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:15Z","timestamp":1777459815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519874901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/0300060519874901"],"URL":"https:\/\/doi.org\/10.1177\/0300060519874901","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]}}}