{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:59:06Z","timestamp":1788339546499,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2018339"],"award-info":[{"award-number":["A2018339"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stomatological Hospital of Southern Medical University Research Training Program","award":["PY2017017"],"award-info":[{"award-number":["PY2017017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the therapeutic effects of one-time root canal treatment versus two-time treatment in patients with irreversible pulpitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We classified 130 patients into a one-time treatment group (group A; n\u2009=\u200968) and a two-time treatment group (group B; n\u2009=\u200962) according to the number of patient visits. Clinical efficacy at 6 months and 1 year follow-ups as well as serum levels of interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein before and 1 week after endodontic treatment were observed. Additionally, the level of treatment satisfaction between the two groups was compared, and the degree of pain was evaluated using the visual analogue scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>One week after treatment, serum interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein levels were significantly decreased in the two groups; however, levels in group B were significantly lower than those in group A. Additionally, visual analogue scale scores of patients in group A were significantly higher than those of patients in group B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One-time root canal therapy can effectively improve postoperative pain and the expression of inflammatory factors in the serum of patients undergoing treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519879287","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T06:54:10Z","timestamp":1571208850000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Therapeutic effect of one-time root canal treatment for irreversible pulpitis"],"prefix":"10.1177","volume":"48","author":[{"given":"Yu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Endodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-5178","authenticated-orcid":false,"given":"Chengxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Stomatological Hospital of Southern Medical University, Guangzhou, Guangdong, 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