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The involvement of many metabolic pathways is reflected in dramatic changes in levels of endogenous small molecule metabolites. Metabolomics represents a promising technique for mechanistic studies and drug screening, and metabonomics, or quantitative metabolomics, has been increasingly applied to the study of hypoxic diseases and their pathogenesis, as well as to pharmacodynamics at high altitudes. In this article, we review the recent literature on the pathogenesis of altitude hypoxia and the clinical and preclinical metabonomics of drug interventions. Endogenous metabolites and metabolic pathways change significantly under high-altitude hypoxia. Some drug interventions have also been shown to regulate pathway metabolism, and the problems of applying metabonomics to hypoxic diseases at high altitude and the prospects for its future application are summarized.<\/jats:p>","DOI":"10.1177\/0300060519879323","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T03:34:28Z","timestamp":1570592068000},"page":"5441-5452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Metabonomics window into plateau hypoxia"],"prefix":"10.1177","volume":"47","author":[{"given":"Yue","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Characteristic Medical Center of People\u2019s Armed Police Force, Tianjin, China"},{"name":"Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Characteristic Medical Center of People\u2019s Armed Police Force, Tianjin, China"},{"name":"Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Characteristic Medical Center of People\u2019s Armed Police Force, Tianjin, China"},{"name":"Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Characteristic Medical Center of People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Characteristic Medical Center of People\u2019s Armed Police Force, Tianjin, China"},{"name":"Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-6842","authenticated-orcid":false,"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment, Tianjin, China"},{"name":"Division of Gastroenterology and Hepatology, Tianjin Xiqing Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"bibr1-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2015.28999.jbw"},{"key":"bibr2-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700527114"},{"key":"bibr3-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1396OC"},{"key":"bibr4-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1528228"},{"key":"bibr5-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010454"},{"key":"bibr6-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1177\/0971102320170106"},{"key":"bibr7-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801581"},{"key":"bibr8-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.25"},{"key":"bibr9-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1157"},{"key":"bibr10-0300060519879323","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809091"},{"key":"bibr11-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.055"},{"key":"bibr12-0300060519879323","doi-asserted-by":"publisher","DOI":"10.1039\/C4MB00119B"},{"key":"bibr13-0300060519879323","doi-asserted-by":"crossref","unstructured":"Tremblay JC, Hoiland RL, Howe CA, et al. 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