{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:25:28Z","timestamp":1792488328383,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated Neem oil and Hypericum perforatum (Holoil\u00ae) for treatment of scleroderma skin ulcers related to calcinosis (SU-calc). Procedure: We retrospectively analyzed 21 consecutive systemic sclerosis (SSc) patients with a total of 33 SU-calcs treated daily with Holoil\u00ae cream compared with a control group of 20 patients with 26 SU-calcs. Holoil\u00ae was directly applied to skin lesions, while the control group received only standard medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Application of Holoil\u00ae either resulted in crushing and complete resolution of calcium deposits or facilitated sharp excision of calcinosis during wound care sessions in 27\/33 cases (81.8%). Complete healing of SU-calc occurred in 15\/33 (45%) of cases within a time period of 40.1\u2009\u00b1\u200916.3 (mean\u2009\u00b1\u2009SD) days, while 18\/33 (55%) of lesions improved in terms of size, erythema, fibrin and calcium deposits. Patients reported a reduction of pain (mean numeric rating scale 7.3\u2009\u00b1\u20091.9 at baseline versus 2.9\u2009\u00b1\u20091.4 at follow-up) The control group had longer healing times and a higher percentage of infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The efficacy of local treatment with neem oil and Hypericum perforatum suggest that Holoil\u00ae could be a promising tool in the management of SSc SU-calc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519882176","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T01:11:18Z","timestamp":1577322678000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Use of Neem oil and\n                    <i>Hypericum perforatum<\/i>\n                    for treatment of calcinosis-related skin ulcers in systemic sclerosis"],"prefix":"10.1177","volume":"48","author":[{"given":"Dilia","family":"Giuggioli","sequence":"first","affiliation":[{"name":"Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Lumetti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Spinella","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cocchiara","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Sighinolfi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103\/287, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Citriniti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Colaci","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Catania, Medical School, AOE Cannizzaro, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"Head of department, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodoveo","family":"Ferri","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, 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