{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:40Z","timestamp":1792787680573,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key projects of Medical Scientific Research in Hebei Province","award":["20180032"],"award-info":[{"award-number":["20180032"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this meta-analysis, we aimed to compare efficacy and clinical outcomes of tolvaptan in treating acute heart failure (AHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using MEDLINE, we searched relevant clinical studies using tolvaptan that investigated clinical effects in treating AHF. We performed meta-analysis for potentially extractable clinical outcomes such as body weight reduction, change in serum sodium levels, and clinical or safety events including worsening heart failure, worsening renal function (WRF), all-cause mortality, rehospitalization, and dyspnea improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that tolvaptan significantly reduced body weight (mean change: \u22121.28\u2009kg, 95% credible interval (CI): \u22121.58\u20130.98), increased serum sodium levels (mean change: 3.48\u2009mmol\/L; 95% Cl: 3.22\u20133.74), and improved dyspnea function (odds ratio (OR): 1.43; 95% CI: 1.26\u20131.62) versus conventional therapy. The event risk of WRF was also significantly reduced (OR: 0.35; 95% CI: 0.15\u20130.80). Low, intermediate, and high tolvaptan doses did not reduce mortality and rehospitalization risks. No significant publication bias was observed regarding effects on mortality and rehospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence indicates that using tolvaptan as add-on therapy can decrease body weight, increase sodium levels, improve dyspnea function, and reverse WRF, which may circumvent loop diuretics overdose and improve outcomes in patients with AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519882221","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T06:22:46Z","timestamp":1572848566000},"page":"5414-5425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Tolvaptan in reversing worsening acute heart failure: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"47","author":[{"given":"Lili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5966-0682","authenticated-orcid":false,"given":"Rongpin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"bibr1-0300060519882221","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2946"},{"key":"bibr2-0300060519882221","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1963"},{"key":"bibr3-0300060519882221","first-page":"7","volume":"17","author":"Lin Y","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"bibr4-0300060519882221","first-page":"300","volume":"26","author":"A CL","year":"2013","journal-title":"J Pharm Pract"},{"key":"bibr5-0300060519882221","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.004"},{"key":"bibr6-0300060519882221","first-page":"936","volume":"39","author":"Li L","year":"2011","journal-title":"Zhonghua Xin Xue Guan Bing Za 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