{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:19:08Z","timestamp":1777727948724,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>The coexistence of lung cancer and pulmonary tuberculosis (PTB) is uncommon in young patients. We report a case of 22-year-old man who presented with a one-month history of chest pain, cough, slight haemoptysis and weight loss. Following two acid fast bacilli positive sputum samples, a diagnosis of TB was concluded. However, his response to anti-TB therapy was inadequate. A CT scan and further laboratory tests assisted the final diagnosis as c-ros oncogene 1 (ROS1) rearranged lung adenocarcinoma and PTB. Despite severe comorbidities, the patient achieved clinical remission following treatment with the anti-cancer drug, crizotinib and anti- TB therapy. Clinicians should be aware that this comorbidity can occur in all age groups and the clinical and radiological symptoms of the two diseases are similar.<\/jats:p>","DOI":"10.1177\/0300060519883752","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T04:13:35Z","timestamp":1575000815000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The coexistence of ROS1-rearranged lung adenocarcinoma and pulmonary tuberculosis in a critical ill young patient"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-5995","authenticated-orcid":false,"given":"Hui","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"bibr1-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.08.007"},{"key":"bibr2-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2013.12.006"},{"key":"bibr3-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30625-X"},{"key":"bibr4-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1166"},{"key":"bibr5-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017479"},{"key":"bibr6-0300060519883752","first-page":"17","volume":"91","author":"Tamura A.","year":"2016","journal-title":"Kekkaku"},{"key":"bibr7-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.009"},{"key":"bibr8-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmyco.2015.07.001"},{"key":"bibr9-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.12.008"},{"key":"bibr10-0300060519883752","doi-asserted-by":"publisher","DOI":"10.5152\/ejp.2016.92485"},{"key":"bibr11-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31823c588d"},{"key":"bibr12-0300060519883752","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5587"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519883752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519883752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519883752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:53Z","timestamp":1777459853000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519883752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/0300060519883752"],"URL":"https:\/\/doi.org\/10.1177\/0300060519883752","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"article-number":"0300060519883752"}}